Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus

doi:10.1016/j.tetlet.2012.01.060

	Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus
	Wang, Lei1,2 ; He, Hong-Ping 1; Di, Ying-Tong1 ; Zhang, Yu1 ; Hao, Xiao-Jiang1
通讯作者	Zhang, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China, zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
	2012-03-28
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	53 期号:13 页码:1576-1578
摘要	Catharoseumine (1), a new monoterpenoid indole alkaloid possessing a unique peroxy bridge moiety, was isolated from the whole plants of Catharanthus roseus. Its structure was elucidated on the basis of NMR, IR, UV, and high-resolution mass spectrometric data, and its absolute configuration was determined by ECD and chemical methods. Catharoseumine (1) exhibited cytotoxicity against HL-60 cell line with IC50 value of 6.28 mu M and potential inhibition against Plasmodium falciparum falcipain-2 (IC50= 4.06 mu M). A plausible biogenetic pathway of 1 was also proposed. (C) 2012 Elsevier Ltd. All rights reserved.
关键词	Catharoseumine Monoterpenoid Indole Alkaloid Perxoxy Bridge Catharanthus Roseus
学科领域	Chemistry, Organic
DOI	10.1016/j.tetlet.2012.01.060
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000301692400011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/10433
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lei,He, Hong-Ping,Di, Ying-Tong,et al. Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus[J]. TETRAHEDRON LETTERS,2012,53(13):1576-1578.
APA	Wang, Lei,He, Hong-Ping,Di, Ying-Tong,Zhang, Yu,&Hao, Xiao-Jiang.(2012).Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus.TETRAHEDRON LETTERS,53(13),1576-1578.
MLA	Wang, Lei,et al."Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus".TETRAHEDRON LETTERS 53.13(2012):1576-1578.

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