Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus
Wang, Lei1,2; He, Hong-Ping1; Di, Ying-Tong1; Zhang, Yu1; Hao, Xiao-Jiang1
Corresponding AuthorZhang, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China, zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2012-03-28
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume53Issue:13Pages:1576-1578
AbstractCatharoseumine (1), a new monoterpenoid indole alkaloid possessing a unique peroxy bridge moiety, was isolated from the whole plants of Catharanthus roseus. Its structure was elucidated on the basis of NMR, IR, UV, and high-resolution mass spectrometric data, and its absolute configuration was determined by ECD and chemical methods. Catharoseumine (1) exhibited cytotoxicity against HL-60 cell line with IC50 value of 6.28 mu M and potential inhibition against Plasmodium falciparum falcipain-2 (IC50= 4.06 mu M). A plausible biogenetic pathway of 1 was also proposed. (C) 2012 Elsevier Ltd. All rights reserved.
KeywordCatharoseumine Monoterpenoid Indole Alkaloid Perxoxy Bridge Catharanthus Roseus
Subject AreaChemistry, Organic
DOI10.1016/j.tetlet.2012.01.060
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000301692400011
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10433
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lei,He, Hong-Ping,Di, Ying-Tong,et al. Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus[J]. TETRAHEDRON LETTERS,2012,53(13):1576-1578.
APA Wang, Lei,He, Hong-Ping,Di, Ying-Tong,Zhang, Yu,&Hao, Xiao-Jiang.(2012).Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus.TETRAHEDRON LETTERS,53(13),1576-1578.
MLA Wang, Lei,et al."Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus".TETRAHEDRON LETTERS 53.13(2012):1576-1578.
Files in This Item: Download All
File Name/Size DocType Version Access License
Wang-2012-Catharoseu(536KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Lei]'s Articles
[He, Hong-Ping]'s Articles
[Di, Ying-Tong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Lei]'s Articles
[He, Hong-Ping]'s Articles
[Di, Ying-Tong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Lei]'s Articles
[He, Hong-Ping]'s Articles
[Di, Ying-Tong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Wang-2012-Catharoseumine, a ne.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.