Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus
Wang, Lei1,2; He, Hong-Ping1; Di, Ying-Tong1; Zhang, Yu1; Hao, Xiao-Jiang1
2012-03-28
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号53期号:13页码:1576-1578
摘要Catharoseumine (1), a new monoterpenoid indole alkaloid possessing a unique peroxy bridge moiety, was isolated from the whole plants of Catharanthus roseus. Its structure was elucidated on the basis of NMR, IR, UV, and high-resolution mass spectrometric data, and its absolute configuration was determined by ECD and chemical methods. Catharoseumine (1) exhibited cytotoxicity against HL-60 cell line with IC50 value of 6.28 mu M and potential inhibition against Plasmodium falciparum falcipain-2 (IC50= 4.06 mu M). A plausible biogenetic pathway of 1 was also proposed. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Catharoseumine Monoterpenoid Indole Alkaloid Perxoxy Bridge Catharanthus Roseus
资助信息National Natural Science Funding of China[30830114, 31100259]; Ministry of Science and Technology[2009CB522300, 2009CB940900]; Young Academic and Technical Leader Raising Foundation of Yunnan Province[2009CI072]; HPC Center of Kunming Institute of Botany (KIB), Chinese Academy of Sciences (CAS)
学科领域Chemistry, Organic
DOI10.1016/j.tetlet.2012.01.060
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000301692400011
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10433
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Wang, Lei,He, Hong-Ping,Di, Ying-Tong,et al. Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus[J]. TETRAHEDRON LETTERS,2012,53(13):1576-1578.
APA Wang, Lei,He, Hong-Ping,Di, Ying-Tong,Zhang, Yu,&Hao, Xiao-Jiang.(2012).Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus.TETRAHEDRON LETTERS,53(13),1576-1578.
MLA Wang, Lei,et al."Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus".TETRAHEDRON LETTERS 53.13(2012):1576-1578.
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