Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases
Mpetga, James D. Simo2,3; Shen, Yu1; Tane, Pierre3; Li, Shi-Fei2; He, Hong-Ping2; Wabo, Hippolyte K.3; Tene, Mathieu3; Leng, Ying1; Hao, Xiao-Jiang2
2012-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:4页码:599-604
摘要Five new triterpenoids, caloncobic acids A and B (1 and 2), caloncobalactones A and B (3 and 4), and glaucalactone (5), along with the known compounds 3 beta,21 beta-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (6) and acetyltrichadenic acid B (7), were isolated from the leaves of Caloncoba glauca. The structures of 1-5 were elucidated using spectroscopic methods. Compounds 1-7 were evaluated for their inhibitory activities against two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1 and 11 beta-HSD2). Compounds 1 and 2 exhibited strong inhibitory activities against mouse (EC50 132 and 13 nM) and human (EC50 105 and 72 nM) 11 beta-HSD1.
关键词Cimicifuga Foetida 4 Alpha-methyl Steroid Cytotoxicity Cimisterol a Performance Liquid-chromatography Light-scattering Detection Black Cohosh Products Euphorbia-chamaesyce Sequence Variation Actaea-racemosa Whole Herb Triterpenoids Constituents Identification
资助信息University of Dschang; Chinese Academy of Sciences (CAS); Academy of Sciences for the Developing World (TWAS)
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np200831c
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000303220500012
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10411
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
3.Univ Dschang, Dept Chem, Lab Nat Prod Chem, Dschang, Cameroon
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Mpetga, James D. Simo,Shen, Yu,Tane, Pierre,et al. Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(4):599-604.
APA Mpetga, James D. Simo.,Shen, Yu.,Tane, Pierre.,Li, Shi-Fei.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2012).Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases.JOURNAL OF NATURAL PRODUCTS,75(4),599-604.
MLA Mpetga, James D. Simo,et al."Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases".JOURNAL OF NATURAL PRODUCTS 75.4(2012):599-604.
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