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题名: Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases
作者: Mpetga, James D. Simo2, 3; Shen, Yu1; Tane, Pierre3; Li, Shi-Fei2; He, Hong-Ping2; Wabo, Hippolyte K.3; Tene, Mathieu3; Leng, Ying1; null(郝小江)2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: Cimicifuga foetida ; 4 alpha-methyl steroid ; Cytotoxicity ; Cimisterol A ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; LIGHT-SCATTERING DETECTION ; BLACK COHOSH PRODUCTS ; EUPHORBIA-CHAMAESYCE ; SEQUENCE VARIATION ; ACTAEA-RACEMOSA ; WHOLE HERB ; TRITERPENOIDS ; CONSTITUENTS ; IDENTIFICATION
英文摘要: Five new triterpenoids, caloncobic acids A and B (1 and 2), caloncobalactones A and B (3 and 4), and glaucalactone (5), along with the known compounds 3 beta,21 beta-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (6) and acetyltrichadenic acid B (7), were isolated from the leaves of Caloncoba glauca. The structures of 1-5 were elucidated using spectroscopic methods. Compounds 1-7 were evaluated for their inhibitory activities against two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1 and 11 beta-HSD2). Compounds 1 and 2 exhibited strong inhibitory activities against mouse (EC50 132 and 13 nM) and human (EC50 105 and 72 nM) 11 beta-HSD1.
出版日期: 2012-04-01
卷号: 75, 期号:4, 页码:599-604
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10411
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
3.Univ Dschang, Dept Chem, Lab Nat Prod Chem, Dschang, Cameroon

Recommended Citation:
Mpetga, JDS; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ.Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases,JOURNAL OF NATURAL PRODUCTS,2012,75(4):599-604
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