| Indole alkaloids from Ervatamia chinensis | |
Guo, Ling-Li1,2 ; He, Hong-Ping1; Di, Ying-Tong1; Li, Shi-Fei1; Cheng, Yuan-Yuan1; Yang, Wei1; Li, Yan1; Yu, Jian-Ping2; Zhang, Yu1; Hao, Xiao-Jiang1
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| Corresponding Author | Zhang, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China, zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn |
| 2012-02-01 | |
| Source Publication | PHYTOCHEMISTRY
 |
| ISSN | 0031-9422 |
| Volume | 74Pages:140-145 |
| Abstract | Four vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC50 values comparable to those of cisplatin. (C) 2011 Elsevier Ltd. All rights reserved. |
| Keyword | Ervatamia Chinensis Apocynaceae Bisindole Alkaloids Ervachinines A-d Cytotoxicity |
| Subject Area | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytochem.2011.11.002 |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000300815700015 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/10369 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Guizhou Univ, Coll Life Sci, Guiyang 550025, Peoples R China |
| Recommended Citation GB/T 7714 | Guo, Ling-Li,He, Hong-Ping,Di, Ying-Tong,et al. Indole alkaloids from Ervatamia chinensis[J]. PHYTOCHEMISTRY,2012,74:140-145. |
| APA | Guo, Ling-Li.,He, Hong-Ping.,Di, Ying-Tong.,Li, Shi-Fei.,Cheng, Yuan-Yuan.,...&Hao, Xiao-Jiang.(2012).Indole alkaloids from Ervatamia chinensis.PHYTOCHEMISTRY,74,140-145. |
| MLA | Guo, Ling-Li,et al."Indole alkaloids from Ervatamia chinensis".PHYTOCHEMISTRY 74(2012):140-145. |
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