Indole alkaloids from Ervatamia chinensis
Guo, Ling-Li1,2; He, Hong-Ping1; Di, Ying-Tong1; Li, Shi-Fei1; Cheng, Yuan-Yuan1; Yang, Wei1; Li, Yan1; Yu, Jian-Ping2; Zhang, Yu1; Hao, Xiao-Jiang1
Corresponding AuthorZhang, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China, zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2012-02-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume74Pages:140-145
AbstractFour vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC50 values comparable to those of cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordErvatamia Chinensis Apocynaceae Bisindole Alkaloids Ervachinines A-d Cytotoxicity
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2011.11.002
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000300815700015
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10369
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Guizhou Univ, Coll Life Sci, Guiyang 550025, Peoples R China
Recommended Citation
GB/T 7714
Guo, Ling-Li,He, Hong-Ping,Di, Ying-Tong,et al. Indole alkaloids from Ervatamia chinensis[J]. PHYTOCHEMISTRY,2012,74:140-145.
APA Guo, Ling-Li.,He, Hong-Ping.,Di, Ying-Tong.,Li, Shi-Fei.,Cheng, Yuan-Yuan.,...&Hao, Xiao-Jiang.(2012).Indole alkaloids from Ervatamia chinensis.PHYTOCHEMISTRY,74,140-145.
MLA Guo, Ling-Li,et al."Indole alkaloids from Ervatamia chinensis".PHYTOCHEMISTRY 74(2012):140-145.
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