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题名: Indole alkaloids from Ervatamia chinensis
作者: null(郭伶俐)1, 2; He, Hong-Ping1; Di, Ying-Tong1; Li, Shi-Fei1; Cheng, Yuan-Yuan1; Yang, Wei1; null(李艳)1; Yu, Jian-Ping2; Zhang, Yu1; null(郝小江)1
刊名: PHYTOCHEMISTRY
关键词: Ervatamia chinensis ; Apocynaceae ; Bisindole alkaloids ; Ervachinines A-D ; Cytotoxicity
英文摘要: Four vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC50 values comparable to those of cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.
出版日期: 2012-02-01
卷号: 74, 页码:140-145
DOI标识: 10.1016/j.phytochem.2011.11.002
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology; Plant Sciences
ISSN号: 0031-9422
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10369
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Guizhou Univ, Coll Life Sci, Guiyang 550025, Peoples R China

Recommended Citation:
Guo, LL; He, HP; Di, YT; Li, SF; Cheng, YY; Yang, W; Li, Y; Yu, JP; Zhang, Y; Hao, XJ.Indole alkaloids from Ervatamia chinensis,PHYTOCHEMISTRY,2012,74():140-145
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