Indole alkaloids from Ervatamia chinensis
Guo, Ling-Li1,2; He, Hong-Ping1; Di, Ying-Tong1; Li, Shi-Fei1; Cheng, Yuan-Yuan1; Yang, Wei1; Li, Yan1; Yu, Jian-Ping2; Zhang, Yu1; Hao, Xiao-Jiang1
2012-02-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号74页码:140-145
摘要Four vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC50 values comparable to those of cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Ervatamia Chinensis Apocynaceae Bisindole Alkaloids Ervachinines A-d Cytotoxicity
资助信息National Basic Research Program of China (973 Program)[2009CB940900, 2009CB522300]; National Natural Science Foundation of China[31100259, 30830114]; Young Academic and Technical Leader Raising Foundation of Yunnan Province[20090072]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2011.11.002
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000300815700015
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10369
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Guizhou Univ, Coll Life Sci, Guiyang 550025, Peoples R China
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Guo, Ling-Li,He, Hong-Ping,Di, Ying-Tong,et al. Indole alkaloids from Ervatamia chinensis[J]. PHYTOCHEMISTRY,2012,74:140-145.
APA Guo, Ling-Li.,He, Hong-Ping.,Di, Ying-Tong.,Li, Shi-Fei.,Cheng, Yuan-Yuan.,...&Hao, Xiao-Jiang.(2012).Indole alkaloids from Ervatamia chinensis.PHYTOCHEMISTRY,74,140-145.
MLA Guo, Ling-Li,et al."Indole alkaloids from Ervatamia chinensis".PHYTOCHEMISTRY 74(2012):140-145.
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