| Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities | |
Dong, Ke1,3; Pu, Jian-Xin1 ; Zhang, Hai-Yan2; Du, Xue1; Li, Xiao-Nian1; Zou, Juan1; Yang, Jian-Hong1; Zhao, Wei1; Tang, Xi-Can2; Sun, Han-Dong1
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| 通讯作者 | Pu, JX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China, pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 2012-02-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 75期号:2页码:249-256 |
| 摘要 | Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against beta-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays. |
| 关键词 | Physalis Peruviana Withanolides Perulactones E-h Withaperuvins I-n Withania-somnifera Steroids Philadelphica |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200937h |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000300601500020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/10359 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Ke,Pu, Jian-Xin,Zhang, Hai-Yan,et al. Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(2):249-256. |
| APA | Dong, Ke.,Pu, Jian-Xin.,Zhang, Hai-Yan.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2012).Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities.JOURNAL OF NATURAL PRODUCTS,75(2),249-256. |
| MLA | Dong, Ke,et al."Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities".JOURNAL OF NATURAL PRODUCTS 75.2(2012):249-256. |
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