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题名: Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities
作者: Dong, Ke1, 3; Pu, Jian-Xin1; Zhang, Hai-Yan2; Du, Xue1; Li, Xiao-Nian1; Zou, Juan1; Yang, Jian-Hong1; Zhao, Wei1; Tang, Xi-Can2; null(孙汉董)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: Physalis peruviana ; Withanolides ; Perulactones E-H ; Withaperuvins I-N ; WITHANIA-SOMNIFERA ; STEROIDS ; PHILADELPHICA
英文摘要: Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against beta-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
出版日期: 2012-02-01
卷号: 75, 期号:2, 页码:249-256
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10359
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Dong, K; Pu, JX; Zhang, HY; Du, X; Li, XN; Zou, J; Yang, JH; Zhao, W; Tang, XC; Sun, HD.Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities,JOURNAL OF NATURAL PRODUCTS,2012,75(2):249-256
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