Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities
Dong, Ke1,3; Pu, Jian-Xin1; Zhang, Hai-Yan2; Du, Xue1; Li, Xiao-Nian1; Zou, Juan1; Yang, Jian-Hong1; Zhao, Wei1; Tang, Xi-Can2; Sun, Han-Dong1
2012-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:2页码:249-256
摘要Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against beta-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
关键词Physalis Peruviana Withanolides Perulactones E-h Withaperuvins I-n Withania-somnifera Steroids Philadelphica
资助信息NSFC[30830115, 20902093]; Science and Technology Program of Yunnan Province[2008GA031]; Major State Basic Research Development Program of China[2009CB522300, 200940900]; Reservation-Talent Project of Yunnan Province
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10359
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Dong, Ke,Pu, Jian-Xin,Zhang, Hai-Yan,et al. Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(2):249-256.
APA Dong, Ke.,Pu, Jian-Xin.,Zhang, Hai-Yan.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2012).Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities.JOURNAL OF NATURAL PRODUCTS,75(2),249-256.
MLA Dong, Ke,et al."Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities".JOURNAL OF NATURAL PRODUCTS 75.2(2012):249-256.
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