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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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植物化学与西部植物资... [8]
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通络方剂对糖尿病大鼠心、肾、腹主动脉血管紧张素水平的影响
期刊论文
实验研究, 3111, 期号: 0, 页码: 139-141
Authors:
宋迎香
;
邹俊杰
;
李文桐
;
张春阳
;
刘岩孙
;
夏培金
;
亮亮
;
曲卫
;
汤玮
;
刘明
;
刘志民
Adobe PDF(272Kb)
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Submit date:2017/07/24
糖尿病
实验性
血管紧张素
通络方剂
大鼠
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
Authors:
Munikishore,Rachakunta
;
Wang,Liang-Liang
;
Zhang,Shuqun
;
Zhao,Qin-Shi
;
Zuo,Zhili
Adobe PDF(523Kb)
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Submit date:2022/04/02
Cathepsin L
small-molecule inhibitor
gram-scale synthesis
KGP94
cancer
FUNCTIONALIZED BENZOPHENONE
BIOLOGICAL EVALUATION
TUMOR PROGRESSION
CELL INVASION
EXPRESSION
ANALOGS
SUPPRESSION
DERIVATIVES
ACID
Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 7188
Authors:
Jin,Min
;
Tang,Congyun
;
Li,Yingying
;
Yang,Shuai
;
Yang,Ying-Tao
;
Peng,Lin
;
Li,Xiao-Nian
;
Zhang,Wenjing
;
Zuo,Zhili
;
Gagosz,Fabien
;
Wang,Liang-Liang
Adobe PDF(2328Kb)
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Submit date:2022/04/02
DIELS-ALDER REACTION
BIOMIMETIC TOTAL-SYNTHESIS
ORTHO-QUINONE METHIDES
BRONSTED ACID
CYCLIZATION
ACTIVATION
OLEFINS
CYCLOADDITIONS
CATALYSIS
ENTRY
Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2021, 卷号: 90, 页码: 107405
Authors:
Jiang,Xuan
;
Li,Shuxiang
;
Zhang,Hongbin
;
Wang,Liang-Liang
Adobe PDF(6441Kb)
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Submit date:2022/04/02
mu-Opioid receptors (MOR)
Biased ligands
Molecular docking
Hip-hop pharmacophore
MD simulation
Psiloboletinus is an independent genus sister to Suillus
期刊论文
MYCOLOGIA, 2020, 卷号: 112, 期号: 1, 页码: 185-196
Authors:
Wu, Gang
;
Wu, Kui
;
Qi, Liang-Liang
;
Morozova, Olga, V
;
Alexandrova, Alina, V
;
Gorbunova, Irina A.
;
Li, Yu
;
Liu, Jian-Wei
;
Yang, Zhu L.
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Submit date:2020/03/18
Larch
multilocus molecular phylogeny
Phylloporus
Suillaceae
taxonomy
Design and synthesis of novel artemisinin hybrids with potent activities against human colorectal cancer cells in vitro and in vivo (vol 182, 111665, 2019)
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Authors:
Wang, Liang-Liang
;
Kong, Lingmei
;
Liu, Hui
;
Zhang, Yunqin
;
Zhang, Li
;
Liu, Xingyong
;
Yuan, Feng
;
Li, Yan
;
Zuo, Zhili
Adobe PDF(169Kb)
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Submit date:2021/01/05
The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Authors:
Xu, Guowei
;
Yang, Yaqing
;
Yang, Yanming
;
Song, Gao
;
Li, Shanshan
;
Zhang, Jiajun
;
Yang, Weimin
;
Wang, Liang-Liang
;
Weng, Zhiying
;
Zuo, Zhili
Adobe PDF(2526Kb)
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Submit date:2021/01/05
Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 10
Authors:
Wang, Liang-Liang
;
Kong, Lingmei
;
Liu, Hui
;
Zhang, Yunqin
;
Zhang, Li
;
Liu, Xingyong
;
Yuan, Feng
;
Li, Yan
;
Zuo, Zhili
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View/Download:62/0
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Submit date:2020/03/02
Artemisinin
Quinazoline
Hybridization
Colorectal cancer
Chemotherapy
Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176
Authors:
Li, Yingying
;
Peng, Jiale
;
Li, Penghua
;
Du, Haibo
;
Li, Yaping
;
Liu, Xingyong
;
Zhang, Li
;
Wang, Liang-Liang
;
Zuo, Zhili
Adobe PDF(7335Kb)
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Submit date:2019/07/29
Pharmacophore modeling
Molecular docking
Quantitative structure activity relationship (QSAR)
Molecular dynamics
AMPK
Activator
2,3-二氢-4(1H)-喹唑啉酮类化合物及其药物组合物和其应用
专利
申请日期: 2019-01-08, 公开日期: 2019-03-29
Inventors:
左之利
;
杨淬
;
汪亮亮
;
李朋华
;
高俐
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Submit date:2019/08/14