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Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:  Lin, Xin;  Tian, Dongsong;  Fu, Yanhui;  Li, Yanan;  Huang, Liejun;  Gu, Wei;  Song, Jialei;  Li, Yanmei;  Ben-David, Yaacov;  Wen, Min;  Yuan, Chunmao;  Hao, Xiaojiang
浏览  |  Adobe PDF(2607Kb)  |  收藏  |  浏览/下载：293/50  |  提交时间：2019/03/18
Polycyclic polyprenylated acylphloroglucinol  Chemical transformation  Cytotoxicity  Cell apoptosis  Cell cycle arrest  
Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 期号: 0, 页码: 381-393
作者:  Yang, Tong-Hua;  Ma, Yun-Bao;  Geng, Chang-An;  Yan, De-Xiu;  Huang, Xiao-Yan;  Li, Tian-Ze;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(2088Kb)  |  收藏  |  浏览/下载：232/75  |  提交时间：2018/10/04
Depression  Magnolol Derivatives  Mt1/2 Receptors  Metabolites  Monoamine Neurotransmitter  
Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 90, 页码: 775-787
作者:  Liu, Chin-Yu;  Cheng, Yung-Yi;  Chang, Ling-Chu;  Huang, Li-Jiau;  Chou, Li-Chen;  Huang, Chi-Hung;  Tsai, Meng-Tung;  Liao, Chih-Chang;  Hsu, Mei-Hua;  Lin, Hui-Yi;  Wu, Tian-Shung;  Wen, Yen-Fang;  Zhao, Yu;  Kuo, Sheng-Chu;  Lee, Kuo-Hsiung;  Kuo,SC (reprint author),China Med Univ,Grad Inst Pharmaceut Chem,91 Hsueh Shih Rd,Taichung 40402,Taiwan.;  sckuo@mail.cmu.edu.tw;  khlee@unc.edu
浏览  |  Adobe PDF(1696Kb)  |  收藏  |  浏览/下载：345/79  |  提交时间：2015/06/29
2-arylnaphthyridin-4-ones  Antitumor Agents  Phosphate Prodrug  
Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 9, 页码: 4238-4244
作者:  Deng, Xu;  Su, Jia;  Zhao, Yu;  Peng, Li-Yan;  Li, Yan;  Yao, Zhu-Jun;  Zhao, Qin-Shi
Adobe PDF(450Kb)  |  收藏  |  浏览/下载：397/99  |  提交时间：2012/03/16
Cheliensisin a  Derivative  Structure-activity Relationship  Cytotoxicity  Anticancer  
Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 1, 页码: 307-319
作者:  Guo, Rui-Hua;  Zhang, Quan;  Ma, Yun-Bao;  Luo, Jie;  Geng, Chang-An;  Wang, Li-Jun;  Zhang, Xue-Mei;  Zhou, Jun;  Jiang, Zhi-Yong;  Chen, Ji-Jun
Adobe PDF(866Kb)  |  收藏  |  浏览/下载：362/92  |  提交时间：2012/04/10
Anti-hepatitis b Virus Activity  Quinolin-2(1h)-one  Structure-activity Relationships