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Novel Inhibitor Cystine Knot Peptides from Momordica charantia 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 10, 页码: e75334
作者:  He, Wen-Jun;  Chan, Lai Yue;  Clark, Richard J.;  Tang, Jun;  Zeng, Guang-Zhi;  Franco, Octavio L.;  Cantacessi, Cinzia;  Craik, David J.;  Daly, Norelle L.;  Tan, Ning-Hua
Adobe PDF(1766Kb)  |  收藏  |  浏览/下载：323/67  |  提交时间：2013/11/12
Amino-acid-sequences  Trypsin-inhibitor  Plasmodium-falciparum  Proteinase-inhibitors  Cytotoxic Cyclotides  Mass-spectrometry  Folding Pathways  Linn Seeds  Kalata B1  X-ray  
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 卷号: 63, 期号: SI, 页码: 485-494
作者:  Liu, Jinhua;  Mu, Chenglong;  Yue, Wen;  Li, Jie;  Ma, Biao;  Zhao, Lixia;  Liu, Lei;  Chen, Quan;  Yan, Chen;  Liu, Haiyang;  Hao, Xiaojiang;  Zhu, Yushan
浏览  |  Adobe PDF(2679Kb)  |  收藏  |  浏览/下载：319/61  |  提交时间：2013/10/16
Thioredoxin Reductase  Bim  Ros  Apoptosis  Cancer  
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntingtons disease 期刊论文
HUMAN MOLECULAR GENETICS, 2013, 卷号: 22, 期号: 18, 页码: 3641-3653
作者:  Wang, Fengli;  Yang, Yeran;  Lin, Xiwen;  Wang, Jiu-Qiang;  Wu, Yong-Sheng;  Xie, Wenjuan;  Wang, Dandan;  Zhu, Shu;  Liao, You-Qi;  Sun, Qinmiao;  Yang, Yun-Gui;  Luo, Huai-Rong;  Guo, Caixia;  Han, Chunsheng;  Tang, Tie-Shan
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Embryonic Stem-cells  Adult Hippocampal Neurogenesis  Transgenic Mouse Model  Dna Methylation  Gene-expression  Mutant Huntingtin  Nervous-system  Polyglutamine Pathogenesis  Mitochondrial Dysfunction  Mammalian Development  
Cloning and characterization of a novel apolipoprotein gene, apolipoprotein AV, in tree shrews 期刊论文
MOLECULAR BIOLOGY REPORTS, 2013, 卷号: 40, 期号: 9, 页码: 5429-5438
作者:  Li, Guoping;  Luo, Huairong;  Sun, Guotao;  Wu, Guisheng;  Wu, Gang;  Wang, Yan;  Man, Yong;  Wang, Shu;  Li, Jian;  Chen, Baosheng
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Apolipoprotein Av  Cdna Sequence  Hdl-c  Recombinant Protein  Tree Shrew  Triglyceride  
Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway 期刊论文
CELL DEATH & DISEASE, 2013, 卷号: 4, 页码: e804
作者:  Deng, Q.;  Yu, X.;  Xiao, L.;  Hu, Z.;  Luo, X.;  Tao, Y.;  Yang, L.;  Liu, X.;  Chen, H.;  Ding, Z.;  Feng, T.;  Tang, Y.;  Weng, X.;  Gao, J.;  Yi, W.;  Bode, A. M.;  Dong, Z.;  Liu, J.;  Cao, Y.
Adobe PDF(1755Kb)  |  收藏  |  浏览/下载：628/73  |  提交时间：2013/11/12
Neoalbaconol  Pdk1  Pi3-k/akt  Energy Depletion  Cancer Cell Death  
Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity 期刊论文
FITOTERAPIA, 2013, 卷号: 89, 页码: 175-182
作者:  Cao, Tuan-Wu;  Geng, Chang-An;  Jiang, Fu-Qiang;  Ma, Yun-Bao;  He, Kang;  Zhou, Ning-Jia;  Zhang, Xue-Mei;  Zhou, Jun;  Chen, Ji-Jun
浏览  |  Adobe PDF(486Kb)  |  收藏  |  浏览/下载：337/92  |  提交时间：2013/10/16
Swertia Yunnanensis  Gentianaceae  Triterpenoids  Sweriyunnanosides A-c  Anti-hbv Activity  
Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling 期刊论文
JOURNAL OF IMMUNOLOGY, 2013, 卷号: 191, 期号: 5, 页码: 2115-2125
作者:  Yin, Qian-Qian;  Liu, Chuan-Xu;  Wu, Ying-Li;  Wu, Shao-Fang;  Wang, Yan;  Zhang, Xia;  Hu, Xiao-Juan;  Pu, Jian-Xin;  Lu, Ying;  Zhou, Hu-Chen;  Wang, Hong-Lin;  Nie, Hong;  Sun, Han-Dong;  Chen, Guo-Qiang
浏览  |  Adobe PDF(2420Kb)  |  收藏  |  浏览/下载：357/47  |  提交时间：2013/10/16
Autoreactive T-cells  Multiple-sclerosis  Rheumatoid-arthritis  Glatiramer Acetate  Activation  Inflammation  System  Roles  Mice  Differentiation  
Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors 期刊论文
ANTIVIRAL RESEARCH, 2013, 卷号: 98, 期号: 3, 页码: 441-448
作者:  Han, Ying-Shan;  Xiao, Wei-Lie;  Quashie, Peter K.;  Mesplede, Thibault;  Xu, Hongtao;  Deprez, Eric;  Delelis, Olivier;  Pu, Jian-Xin;  Sun, Han-Dong;  Wainberg, Mark A.
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Hiv-1 Integrase Inhibitors  Integrase Dna Binding  Fluorescent Assay  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Transcriptome Exploration in Leymus chinensis under Saline-Alkaline Treatment Using 454 Pyrosequencing 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 1, 页码: e53632-
作者:  Sun, Yepeng;  Wang, Fawei;  Wang, Nan;  Dong, Yuanyuan;  Liu, Qi;  Zhao, Lei;  Chen, Huan;  Liu, Weican;  Yin, Hailong;  Zhang, Xiaomei;  Yuan, Yanxi;  Li, Haiyan
浏览  |  Adobe PDF(1039Kb)  |  收藏  |  浏览/下载：290/82  |  提交时间：2013/03/18
Gene-expression  Differential Display  Lipid-peroxidation  Plasma-membrane  Inner-mongolia  Messenger-rna  Calcium  Plants  Hybridization  Genotypes