Immunosuppressive leucosesterterpane and penta-nor-leucosesterterpane sesterterpenoids from Leucosceptrum canum

doi:10.1016/j.phytochem.2024.114185

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	Immunosuppressive leucosesterterpane and penta-nor-leucosesterterpane sesterterpenoids from Leucosceptrum canum
	Zhou, Ting -Ting; Zhang, Man -Wen; Liu, Yan-Chun; Li, Xiao-Nian; Liu, Yan; Guo, Kai; Li, Sheng-Hong
	2024
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	225 页码:114185
摘要	Five undescribed leucosesterterpane sesterterpenoids, leucosceptrines A-E, two undescribed penta-nor-leucosesterterpane (C20) sesterterpenoids, nor-leucosceptrines A and B, and three known analogues, were obtained from the aerial parts of Leucosceptrum canum of Chinese origin. Leucosceptrines A-C are the first examples of leucosesterterpane-type sesterterpenoids with unclosed dihydropyran rings and reverse configurations at chiral centers C-4 and/or C-12. Nor-leucosceptrines A and B possesses an unusual penta-nor-leucosesterterpane skeleton. Their structures were unambiguously elucidated through comprehensive spectroscopic analyses and singlecrystal X-ray diffraction. A plausible biogenetic pathway for these sesterterpenoids was proposed. The immunosuppressive effects of these isolates on the secretion of the cytokine IFN-gamma by T cells stimulated with anti-CD3/ CD28 monoclonal antibodies were observed with different potencies.
DOI	10.1016/j.phytochem.2024.114185
WOS记录号	WOS:001255593800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76388
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhou, Ting -Ting,Zhang, Man -Wen,Liu, Yan-Chun,et al. Immunosuppressive leucosesterterpane and penta-nor-leucosesterterpane sesterterpenoids from Leucosceptrum canum[J]. PHYTOCHEMISTRY,2024,225:114185.
APA	Zhou, Ting -Ting.,Zhang, Man -Wen.,Liu, Yan-Chun.,Li, Xiao-Nian.,Liu, Yan.,...&Li, Sheng-Hong.(2024).Immunosuppressive leucosesterterpane and penta-nor-leucosesterterpane sesterterpenoids from Leucosceptrum canum.PHYTOCHEMISTRY,225,114185.
MLA	Zhou, Ting -Ting,et al."Immunosuppressive leucosesterterpane and penta-nor-leucosesterterpane sesterterpenoids from Leucosceptrum canum".PHYTOCHEMISTRY 225(2024):114185.

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