Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition

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	Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition
	Long, Xianwen; Zhang, Min; Yang, Xiaodong; Deng, Jun
	2022
发表期刊	ORGANIC LETTERS
卷号	24 期号:6 页码:1303-1307
摘要	A bioinspired strategy is described for the total synthesis of spiroaxillarone A, which exhibited significant antimalarial activity against resistant Plasmodium falciparum (IC50 = 2.32 mu M). The key steps include an intermolecular ethanethiol Michael addition, o-quinone Michael addition, and subsequent beta-ethanethiol elimination. This synthetic sequence provides a potential biosynthetic pathway of spiroaxillarone A.
关键词	LIGANDS THIOLS
DOI	10.1021/acs.orglett.1c04282
收录类别	SCI
WOS记录号	WOS:000758180800008
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75664
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Long, Xianwen,Zhang, Min,Yang, Xiaodong,et al. Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition[J]. ORGANIC LETTERS,2022,24(6):1303-1307.
APA	Long, Xianwen,Zhang, Min,Yang, Xiaodong,&Deng, Jun.(2022).Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition.ORGANIC LETTERS,24(6),1303-1307.
MLA	Long, Xianwen,et al."Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition".ORGANIC LETTERS 24.6(2022):1303-1307.