Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes

doi:10.1039/d3fo01130e

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	Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes
	Wang,Qian; Hu,Guilin; Lu,Qian; Hong,Defu; Al-Romaima,Abdulbaset; Qiu,Minghua; Xiong,Wenyong
	2023
发表期刊	FOOD & FUNCTION
ISSN	2042-650X
卷号	14 期号:11 页码:5138-5150
摘要	Previous studies have shown that coffee has a role in regulating lipid metabolism. However, the active compounds and pharmacological mechanism(s) are still unclear. Here, four new coffee diterpenoids (1-4) were identified from roasted arabica coffee (Coffea arabica L.) beans, and together with 31 known coffee diterpenoids (5-35), their bioactivities in the regulation of lipid content in white adipocytes were evaluated. Based on their structures and correlated bioactivities, we proposed that the alpha,beta-unsaturated-gamma-lactone moiety and hydroxyl group at C-3 are required for the bioactivity. Furthermore, the pharmacological approaches revealed that the active new diterpenoid, dehydrocaffarolide B, inhibited the Akt/mTOR/GSK3 beta pathway and arrested cells in the G0/G1 phase of the mitotic clonal expansion process during the adipocyte differentiation and maturation, eventually resulting in the blunting of lipid accumulation in the adipocytes. Collectively, our findings identified four new diterpenoids of arabica coffee and elucidated a mechanism of an active lactone-type diterpenoid in the regulation of lipid content in white adipocytes.
关键词	ACCUMULATION CAFESTOL KAHWEOL BEANS DIFFERENTIATION
学科领域	Biochemistry & Molecular Biology ; Food Science & Technology
DOI	10.1039/d3fo01130e
收录类别	SCI
WOS记录号	WOS:000986884400001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75616
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Qian,Hu,Guilin,Lu,Qian,et al. Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes[J]. FOOD & FUNCTION,2023,14(11):5138-5150.
APA	Wang,Qian.,Hu,Guilin.,Lu,Qian.,Hong,Defu.,Al-Romaima,Abdulbaset.,...&Xiong,Wenyong.(2023).Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes.FOOD & FUNCTION,14(11),5138-5150.
MLA	Wang,Qian,et al."Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes".FOOD & FUNCTION 14.11(2023):5138-5150.

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