Identification of undescribed key impurities of homoharringtonine bulk drug

doi:10.1080/14786419.2023.2175358

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	Identification of undescribed key impurities of homoharringtonine bulk drug
	Yu,Yang; Wu,Jing; Yue,Cong-Yong; Zhang,Tao; Cai,Xiang-Hai
	2023
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6427
摘要	The knowledge of impurities is an important issue and the base of quality control in modern drugs. To date, the quality control of the antitumor drug homoharringtonine (HHT) is still not sufficiently solved and needs to be improved. Six main impurities, drupacine, cephalotaxine, desmethylcephalotaxinone, harringtonine, 3-O-acetyl-cephalotaxine and 2'R,3'S-isoharringtonine were traced during HHT drug production by HPLC and LC-MS analyses. Additionally, we were able to isolate and identify three undescribed key trace impurities, neohomoharringtonines A-C. Their structures were established by 1D-, and 2D NMR experiments combined with mass spectrometry. An improved quality inspection ability of HHT was constructed.
关键词	Cephalotaxus fortunei neohomoharringtonines A-C homoharringtonine structure identification key impurities
学科领域	Chemistry ; Pharmacology & Pharmacy
DOI	10.1080/14786419.2023.2175358
收录类别	SCI
WOS记录号	WOS:000934342900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75539
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yu,Yang,Wu,Jing,Yue,Cong-Yong,et al. Identification of undescribed key impurities of homoharringtonine bulk drug[J]. NATURAL PRODUCT RESEARCH,2023.
APA	Yu,Yang,Wu,Jing,Yue,Cong-Yong,Zhang,Tao,&Cai,Xiang-Hai.(2023).Identification of undescribed key impurities of homoharringtonine bulk drug.NATURAL PRODUCT RESEARCH.
MLA	Yu,Yang,et al."Identification of undescribed key impurities of homoharringtonine bulk drug".NATURAL PRODUCT RESEARCH (2023).

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