The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions

doi:10.1016/j.jff.2023.105607

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	The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions
	Yang,Mei-Xia; Cheng,Edwin Hok-Chi; Ospondpant,Dusadee; Tung,Ka-Ki; Wang,Li-Song; Lin,Sheng-Ying; Lai,Queenie Wing-Sze; Wu,Qi-Yun; Xia,Ying-Jie; Leung,Ka-Wing; Duan,Ran; Dong,Tina Ting-Xia; Tsim,Karl Wah-Keung
	2023
发表期刊	JOURNAL OF FUNCTIONAL FOODS
ISSN	2214-9414
卷号	107 页码:105607
摘要	Lobaria pindarensis Rasanen is an edible and medicinal lichen found in the Himalayas that has been used as ethnomedicine for years to combat inflammation. The study aimed to evaluate the ability of L. pindarensis extracts and its main depsidones to suppress inflammation and A beta fibril formation in cultured cells induced by LPS or A beta 42. The mRNA and protein expressions of inflammatory cytokines were declined significantly by the applied herbal extracts and depsidones in the LPS/A beta-treated immune cells (p < 0.05 to p < 0.001). In addition, the extracts and depsidones of L. pindarensis showed enhancement of phagocytotic function of microglia and disassembling aggregated A beta fibrils in dose-dependent manners (p < 0.05 to p < 0.001). The study presents the first evidence that L. pindarensis extracts have the potential to suppress inflammation and A beta fibril protein aggregation, making it a promising candidate for developing health food supplements for Alzheimer's patients.
关键词	Alzheimer's disease Inflammation Fibrillar A beta Lichen Lobaria pindarensis Depsidone IN-SILICO IDENTIFICATION INHIBITORS
DOI	10.1016/j.jff.2023.105607
收录类别	SCI
WOS记录号	WOS:001037290100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75492
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang,Mei-Xia,Cheng,Edwin Hok-Chi,Ospondpant,Dusadee,et al. The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions[J]. JOURNAL OF FUNCTIONAL FOODS,2023,107:105607.
APA	Yang,Mei-Xia.,Cheng,Edwin Hok-Chi.,Ospondpant,Dusadee.,Tung,Ka-Ki.,Wang,Li-Song.,...&Tsim,Karl Wah-Keung.(2023).The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions.JOURNAL OF FUNCTIONAL FOODS,107,105607.
MLA	Yang,Mei-Xia,et al."The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions".JOURNAL OF FUNCTIONAL FOODS 107(2023):105607.

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