Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

doi:10.1038/s41467-023-37459-z

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	Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
	Zhao,Qi; Dai,Man-Yun; Huang,Ruo-Yue; Duan,Jing-Yi; Zhang,Ting; Bao,Wei-Min; Zhang,Jing-Yi; Gui,Shao-Qiang; Xia,Shu-Min; Dai,Cong-Ting; Tang,Ying-Mei; Gonzalez,Frank J. J.; Li,Fei
	2023
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	14 期号:1 页码:1829
摘要	Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. distasonis to male mice improves thioacetamide (TAA)- and methionine and choline-deficient (MCD) diet-induced hepatic fibrosis. Administration of P. distasonis also leads to increased bile salt hydrolase (BSH) activity, inhibition of intestinal farnesoid X receptor (FXR) signaling and decreased taurochenodeoxycholic acid (TCDCA) levels in liver. TCDCA produces toxicity in mouse primary hepatic cells (HSCs) and induces mitochondrial permeability transition (MPT) and Caspase-11 pyroptosis in mice. The decrease of TCDCA by P. distasonis improves activation of HSCs through decreasing MPT-Caspase-11 pyroptosis in hepatocytes. Celastrol, a compound reported to increase P. distasonis abundance in mice, promotes the growth of P. distasonis with concomitant enhancement of bile acid excretion and improvement of hepatic fibrosis in male mice. These data suggest that supplementation of P. distasonis may be a promising means to ameliorate hepatic fibrosis. Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P. distasonis ameliorates liver fibrosis in studies with male mice, potentially via altered bile acid metabolism and hepatocyte pyroptosis.
关键词	FATTY LIVER-DISEASE INDUCED CHOLESTASIS STELLATE CELLS PROBIOTICS PROTECTS INFLAMMATION APOPTOSIS OBESITY AXIS
学科领域	Science & Technology - Other Topics
DOI	10.1038/s41467-023-37459-z
WOS记录号	WOS:000962482700009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74865
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhao,Qi,Dai,Man-Yun,Huang,Ruo-Yue,et al. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice[J]. NATURE COMMUNICATIONS,2023,14(1):1829.
APA	Zhao,Qi.,Dai,Man-Yun.,Huang,Ruo-Yue.,Duan,Jing-Yi.,Zhang,Ting.,...&Li,Fei.(2023).Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice.NATURE COMMUNICATIONS,14(1),1829.
MLA	Zhao,Qi,et al."Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice".NATURE COMMUNICATIONS 14.1(2023):1829.

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