FXR activation prevents liver injury induced by Tripterygium wilfordii preparations

doi:10.1080/00498254.2021.1900626

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	FXR activation prevents liver injury induced by Tripterygium wilfordii preparations
	Peng,Wan; Dai,Man-Yun ; Bao,Li-Juan ; Zhu,Wei-Feng ; Li,Fei
	2021
发表期刊	XENOBIOTICA
ISSN	0049-8254
卷号	51 期号:6 页码:716-727
摘要	Tripterygium glycosides tablets (TGT) and Tripterygium wilfordii tablets (TWT) are the preparations of Tripterygium wilfordii used to treat rheumatoid arthritis (RA) in the clinic, but the hepatotoxicity was reported frequently. This study aimed to determine the potential toxicity mechanism of liver injury induced by the preparations of Tripterygium wilfordii in mice.Here, we performed metabolomic analysis, pathological analysis and biochemical analysis of samples from mice with liver injury induced by TGT and TWT, which revealed that liver injury was associated with bile acid metabolism disorder. Quantitative real-time PCR (QPCR) and western blot indicated that the above changes were accompanied by inhibition of farnesoid X receptor (FXR) signalling.Liver injury from TWT could be alleviated by treatment of the FXR agonist obeticholic acid (OCA) via activation of the FXR to inhibit the c-Jun N-terminal kinase (JNK) pathway and improve bile acid metabolism disorder by activating bile salt export pump (BSEP) and organic solute-transporter-beta (OSTB). The data demonstrate that FXR signalling pathway plays a key role in T. wilfordii-induced liver injury, which could be alleviated by activated FXR.These results indicate that FXR activation by OCA may offer a promising therapeutic opportunity against hepatotoxicity from the preparations of T. wilfordii.
关键词	Tripterygium wilfordii liver injury farnesoid X receptor bile acid metabolism metabolomics
DOI	10.1080/00498254.2021.1900626
WOS记录号	WOS:000635403000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73529
专题	中国科学院昆明植物研究所
作者单位	1.[Peng, Wan 2.Dai, Man-Yun 3.Bao, Li-Juan 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Sichuan Univ, West China Hosp, Lab Metabol & Drug Induced Liver Injury, Frontiers Sci Ctr Dis Related Mol Network, Chengdu 610065, Peoples R China 7.Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian, Shaanxi, Peoples R China 8.Jiangxi Univ Tradit Chinese Med, Academician Workstn, Nanchang, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Peng,Wan,Dai,Man-Yun,Bao,Li-Juan,et al. FXR activation prevents liver injury induced by Tripterygium wilfordii preparations[J]. XENOBIOTICA,2021,51(6):716-727.
APA	Peng,Wan,Dai,Man-Yun,Bao,Li-Juan,Zhu,Wei-Feng,&Li,Fei.(2021).FXR activation prevents liver injury induced by Tripterygium wilfordii preparations.XENOBIOTICA,51(6),716-727.
MLA	Peng,Wan,et al."FXR activation prevents liver injury induced by Tripterygium wilfordii preparations".XENOBIOTICA 51.6(2021):716-727.

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