Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis

doi:10.1021/acs.orglett.1c00369

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	Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis
	Teng,Lin-Lin ; Mu,Rong-Fang ; Liu,Yan-Chun ; Xiao,Chao-Jiang ; Li,De-Sen ; Gao,Jian-Xiong ; Guo,Kai ; Li,Xiao-Nian ; Liu,Yan ; Zeng,Fang ; Li,Sheng-Hong
	2021
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	23 期号:6 页码:2232-2237
摘要	Eurysoloids A (1) and B (2), two novel diastereomeric sesterterpenoids possessing a pentacyclic 5/6/5/10/5 framework with an unusual macrocyclic ether system, were isolated from Eurysolen gracilis Frain. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction and DP4+ analyses. A plausible biosynthetic pathway for compounds 1 and 2 was proposed. Both compounds exhibited immunosuppressive activity via inhibiting the production of cytokine IFN-gamma of T cells, and compound 2 inhibited adipogenesis in 3T3-L1 adipocytes.
DOI	10.1021/acs.orglett.1c00369
WOS记录号	WOS:000631439700052
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73511
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Dali Univ, Inst Mat Med, Dali 671000, Peoples R China 5.Dali Univ, Coll Pharm, Dali 671000, Peoples R China 6.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 7.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 8.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 611137, Peoples R China
推荐引用方式 GB/T 7714	Teng,Lin-Lin,Mu,Rong-Fang,Liu,Yan-Chun,et al. Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis[J]. ORGANIC LETTERS,2021,23(6):2232-2237.
APA	Teng,Lin-Lin.,Mu,Rong-Fang.,Liu,Yan-Chun.,Xiao,Chao-Jiang.,Li,De-Sen.,...&Li,Sheng-Hong.(2021).Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis.ORGANIC LETTERS,23(6),2232-2237.
MLA	Teng,Lin-Lin,et al."Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis".ORGANIC LETTERS 23.6(2021):2232-2237.

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