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C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum
Yuan,Hai-Lian; Zhao,Yun-Li; Hu,Kun; He,Ying-Jie; Yang,Xing-Wei; Luo,Xiao-Dong
2021
发表期刊JOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
卷号86期号:23页码:16764-16769
摘要Hyperectumine (1), the first C-19 benzylisoquinoline alkaloid with a complicated ring system, was isolated from Hypecoum erectum and structurally characterized. Its biosynthetic origin should involve a hybrid pattern of C-8 + C-8 + C-1 + C-2, from which a C-17 benzylisoquinoline alkaloid might be further attacked by a malonamic acid and undergo decarboxylation and cyclization to produce 1. Compound (-)-1 exhibited moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.
关键词OPIUM POPPY BIOSYNTHESIS APORPHINE TETRANDRINE PAPAVERINE DISCOVERY
DOI10.1021/acs.joc.1c01990
WOS记录号WOS:000752848600045
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73428
专题中国科学院昆明植物研究所
作者单位1.[Yuan, Hai-Lian
2.Hu, Kun
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.[Zhao, Yun-Li
5.He, Ying-Jie
6.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China
7.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China
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Yuan,Hai-Lian,Zhao,Yun-Li,Hu,Kun,et al. C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(23):16764-16769.
APA Yuan,Hai-Lian,Zhao,Yun-Li,Hu,Kun,He,Ying-Jie,Yang,Xing-Wei,&Luo,Xiao-Dong.(2021).C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum.JOURNAL OF ORGANIC CHEMISTRY,86(23),16764-16769.
MLA Yuan,Hai-Lian,et al."C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum".JOURNAL OF ORGANIC CHEMISTRY 86.23(2021):16764-16769.
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