C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum

doi:10.1021/acs.joc.1c01990

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	C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum
	Yuan,Hai-Lian ; Zhao,Yun-Li ; Hu,Kun; He,Ying-Jie ; Yang,Xing-Wei; Luo,Xiao-Dong
	2021
发表期刊	JOURNAL OF ORGANIC CHEMISTRY
ISSN	0022-3263
卷号	86 期号:23 页码:16764-16769
摘要	Hyperectumine (1), the first C-19 benzylisoquinoline alkaloid with a complicated ring system, was isolated from Hypecoum erectum and structurally characterized. Its biosynthetic origin should involve a hybrid pattern of C-8 + C-8 + C-1 + C-2, from which a C-17 benzylisoquinoline alkaloid might be further attacked by a malonamic acid and undergo decarboxylation and cyclization to produce 1. Compound (-)-1 exhibited moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.
关键词	OPIUM POPPY BIOSYNTHESIS APORPHINE TETRANDRINE PAPAVERINE DISCOVERY
DOI	10.1021/acs.joc.1c01990
WOS记录号	WOS:000752848600045
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73428
专题	中国科学院昆明植物研究所
作者单位	1.[Yuan, Hai-Lian 2.Hu, Kun 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.[Zhao, Yun-Li 5.He, Ying-Jie 6.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 7.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China
推荐引用方式 GB/T 7714	Yuan,Hai-Lian,Zhao,Yun-Li,Hu,Kun,et al. C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(23):16764-16769.
APA	Yuan,Hai-Lian,Zhao,Yun-Li,Hu,Kun,He,Ying-Jie,Yang,Xing-Wei,&Luo,Xiao-Dong.(2021).C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum.JOURNAL OF ORGANIC CHEMISTRY,86(23),16764-16769.
MLA	Yuan,Hai-Lian,et al."C-19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum".JOURNAL OF ORGANIC CHEMISTRY 86.23(2021):16764-16769.

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