3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.

doi:10.1021/acs.jnatprod.0c01305

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	3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.
	Zhou,Yuan-Fei ; Hu,Kun; Wang,Fang ; Tang,Jian-Wei ; Zhang,Liang ; Sun,Han-Dong; Cai,Xiang-Hai; Puno,Pema-Tenzin
	2021
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	84 期号:4 页码:1244-1253
摘要	An investigation of an endolichenic Beauveria sp. led to the discovery of seven new cyclotetradepsipeptides, beauveamides A-G (2-8), along with the known beauverolide Ka (1). All incorporate a 3-hydroxy-4-methyldecanoic acid (HMDA) moiety in their structures. Their configuration was determined through Marfey's, J-based configuration analysis, and NMR computational methods, representing the first time that the stereostructures of HMDA-moiety-containing cyclotetradepsipeptides have been established. Compounds 1 and 2 exhibited protecting effects on HEI-OC1 cells at 10 mu M, while 1, 4, and 5 could stimulate glucose uptake in cultured rat L6 myoblasts at 50 mu M. Compound 1 showed dose-dependent activity in both L6 myoblasts and myotubes.
关键词	DOUBLE-BLIND CYCLODEPSIPEPTIDES CONFIGURATION METABOLITES SUROTOMYCIN VANCOMYCIN ADULTS FUNGI H-1
DOI	10.1021/acs.jnatprod.0c01305
WOS记录号	WOS:000644478400032
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73364
专题	中国科学院昆明植物研究所
作者单位	1.[Zhou, Yuan-Fei 2.Hu, Kun 3.Wang, Fang 4.Tang, Jian-Wei 5.Zhang, Liang 6.Sun, Han-Dong 7.Cai, Xiang-Hai 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhou,Yuan-Fei,Hu,Kun,Wang,Fang,et al. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1244-1253.
APA	Zhou,Yuan-Fei.,Hu,Kun.,Wang,Fang.,Tang,Jian-Wei.,Zhang,Liang.,...&Puno,Pema-Tenzin.(2021).3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp..JOURNAL OF NATURAL PRODUCTS,84(4),1244-1253.
MLA	Zhou,Yuan-Fei,et al."3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1244-1253.

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