Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China

doi:10.1016/j.bioorg.2021.104785

KIB OpenIR

	Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China
	Wang,Bin; Hu,Kun; Li,Xiao-Nian ; Sun,Han-Dong; Qin,Hong-Bo; Puno,Pema-Tenzin
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	110 页码:104785
摘要	Schisdilactones K?U (1?11), a series of previously unreported 16,17-secopreschisanartane-type schinortriterpenoids (SNTs), were isolated from the leaves and stems of Schisandra neglecta A. C. Smith. Their structures were mainly established through analysis of their spectroscopic data. Besides, schisdilactones K (1), O (5) and R (8) were confirmed by single-crystal X-ray crystallographic analysis, and the configurations of schisdilactones T and U (10 and 11) were elucidated via quantum chemical calculation of their NMR chemical shifts and electronic circular dichroism (ECD) spectra. Schisdilactones L?S (2?8) and U (11) were found to exhibit moderate protective activities against corticosterone-induced apoptosis of PC12 cells at 20 ?M, with cell viability in the range of 62.95?66.97%.
关键词	Schisandra neglecta 16 17-secopreschisanartane-type schinortriterpenoids Schisdilactones K?U Quantum chemical calculation Neuroprotective activity DIBENZOCYCLOOCTADIENE LIGNANS NORTRITERPENOIDS CHINENSIS STEMS 7,8-SECOLIGNANS TRITERPENOIDS
DOI	10.1016/j.bioorg.2021.104785
WOS记录号	WOS:000744355400004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73350
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources We, Kunming, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang,Bin,Hu,Kun,Li,Xiao-Nian,et al. Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China[J]. BIOORGANIC CHEMISTRY,2021,110:104785.
APA	Wang,Bin,Hu,Kun,Li,Xiao-Nian,Sun,Han-Dong,Qin,Hong-Bo,&Puno,Pema-Tenzin.(2021).Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China.BIOORGANIC CHEMISTRY,110,104785.
MLA	Wang,Bin,et al."Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China".BIOORGANIC CHEMISTRY 110(2021):104785.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
031-C04-148-王-BC.pdf（2463KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载