Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2

doi:10.1039/d1qo00294e

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	Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2
	Peng,Xingrong ; Su,Haiguo ; Wang,Huirong ; Hu,Guilin ; Hu,Kun; Zhou,Lin ; Qiu,Minghua
	2021
发表期刊	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
卷号	8 期号:13 页码:3381-3389
摘要	Two unprecedented Ganoderma meroterpenoid dimers, applanmerotic acids A and B (1 and 2), were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including stereostructures were established by spectroscopic analysis and the quantum chemical calculation (calculated C-13 NMR and electronic circular dichroism) method. Compound 1 was a pair of enantiomers and compound 2 represents the first example of a dimeric meroterpenoid with a 2-oxo-spiro[furo[3,2-b]benzofuran-3,2 '-naphthalene] core. Their plausible biogenetic pathway was proposed, from which their key polycyclic cores were formed through an intermolecular Diels-Alder reaction. Compounds 1 and 2 showed anti-inflammatory activities with IC50 values of 14.5 and 20.9 mu M, respectively, by inhibiting the activation of FPR2 and the further competitive binding assay and molecular docking study indicated their action mechanism.
DOI	10.1039/d1qo00294e
WOS记录号	WOS:000644864900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73345
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Peng,Xingrong,Su,Haiguo,Wang,Huirong,et al. Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(13):3381-3389.
APA	Peng,Xingrong.,Su,Haiguo.,Wang,Huirong.,Hu,Guilin.,Hu,Kun.,...&Qiu,Minghua.(2021).Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2.ORGANIC CHEMISTRY FRONTIERS,8(13),3381-3389.
MLA	Peng,Xingrong,et al."Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2".ORGANIC CHEMISTRY FRONTIERS 8.13(2021):3381-3389.

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