A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

doi:10.1093/molbev/msab263

KIB OpenIR

	A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution
	Yang,Hui ; Yang,Songlin ; Fan,Fei ; Li,Yun ; Dai,Shaoxing ; Zhou,Xin ; Steiner,Cynthia C.; Coppedge,Bretton ; Roos,Christian ; Cai,Xianghai; Irwin,David M.; Shi,Peng
	2021
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	38 期号:12 页码:5472-5479
摘要	Bitter taste receptors serve as a vital component in the defense system against toxin intake by animals, and the family of genes encoding these receptors has been demonstrated, usually by family size variance, to correlate with dietary preference. However, few systematic studies of specific Tas2R to unveil their functional evolution have been conducted. Here, we surveyed Tas2R16 across all major clades of primates and reported a rare case of a convergent change to increase sensitivity to beta-glucopyranosides in human and a New World monkey, the white-faced saki. Combining analyses at multiple levels, we demonstrate that a parallel amino acid substitution (K172N) shared by these two species is responsible for this functional convergence of Tas2R16. Considering the specialized feeding preference of the white-faced saki, the K172N change likely played an important adaptive role in its early evolution to avoid potentially toxic cyanogenic glycosides, as suggested for the human TAS2R16 gene.
关键词	convergent evolution bitter taste receptors Tas2R16 human white-faced saki Pithecia pithecia adaptive evolution PHYLOGENETIC ANALYSIS SENSITIVITY DIVERSITY SELECTION TAS2R16 OPTIMIZATION CONVERGENT PLATFORM DOCKING FAMILY
DOI	10.1093/molbev/msab263
WOS记录号	WOS:000741368600017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73162
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Beckman Ctr Conservat Res, San Diego Zoo Wildlife Alliance, Escondido, CA USA 4.Leibniz Inst Primate Res, German Primate Ctr, Gene Bank Primates & Primate Genet Lab, Gottingen, Germany 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources We, Kunming, Yunnan, Peoples R China 6.Irwin, David M.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada 7.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yang,Hui,Yang,Songlin,Fan,Fei,et al. A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(12):5472-5479.
APA	Yang,Hui.,Yang,Songlin.,Fan,Fei.,Li,Yun.,Dai,Shaoxing.,...&Shi,Peng.(2021).A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.MOLECULAR BIOLOGY AND EVOLUTION,38(12),5472-5479.
MLA	Yang,Hui,et al."A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution".MOLECULAR BIOLOGY AND EVOLUTION 38.12(2021):5472-5479.