Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces
Yang, Feng-Xian2,3; Huang, Jian-Ping2; Liu, Zhixiang1; Wang, Zhiyan2,3; Yang, Jing2; Tang, Jun2,3; Yu, Zhiyin2; Yan, Yijun2; Kai, Guoyin1; Huang, Sheng-Xiong2
Corresponding AuthorKai, Guoyin(kaiguoyin@163.com) ; Huang, Sheng-Xiong(sxhuang@mail.kib.ac.cn)
2020
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume83Issue:1Pages:111-117
AbstractSeven new trialkyl-substituted benzene derivatives named benwamycins A-G (1-7), together with three known congeners, 8-10, were isolated from culture broth of the soil-derived Streptomyces sp. KIB-H1471. Their structures were elucidated by. using 1D and 2D NMR analyses in combination with HRESIMS data. The absolute configurations of 1-9 were determined by chemical conversion and comparison of circular dichroism spectra and confirmed for 1 by single-crystal X-ray crystallography. Compounds 6 and 7 have a unique gamma-pyrone-like ring on one side chain. Compounds 2 and 6 inhibited human T cell proliferation with IC50 values of 14.3 and 12.5 mu M, respectively, without obvious cytotoxicity for naive human T cells. Compounds 3 and 6 could weakly enhance insulin-stimulated glucose uptake.
DOI10.1021/acs.jnatprod.9b00903
Indexed BySCI ; SCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000510076700015
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70890
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorKai, Guoyin; Huang, Sheng-Xiong
Affiliation1.Zhejiang Chinese Med Univ, Hangzhou, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yang, Feng-Xian,Huang, Jian-Ping,Liu, Zhixiang,et al. Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(1):111-117.
APA Yang, Feng-Xian.,Huang, Jian-Ping.,Liu, Zhixiang.,Wang, Zhiyan.,Yang, Jing.,...&Huang, Sheng-Xiong.(2020).Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces.JOURNAL OF NATURAL PRODUCTS,83(1),111-117.
MLA Yang, Feng-Xian,et al."Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces".JOURNAL OF NATURAL PRODUCTS 83.1(2020):111-117.
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