Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces

doi:10.1021/acs.jnatprod.9b00903

	Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces
	Yang, Feng-Xian 2,3; Huang, Jian-Ping 2; Liu, Zhixiang 1; Wang, Zhiyan 2,3; Yang, Jing2 ; Tang, Jun 2,3; Yu, Zhiyin 2; Yan, Yijun 2; Kai, Guoyin 1; Huang, Sheng-Xiong2
通讯作者	Kai, Guoyin(kaiguoyin@163.com) ; Huang, Sheng-Xiong(sxhuang@mail.kib.ac.cn)
	2020
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	83 期号:1 页码:111-117
摘要	Seven new trialkyl-substituted benzene derivatives named benwamycins A-G (1-7), together with three known congeners, 8-10, were isolated from culture broth of the soil-derived Streptomyces sp. KIB-H1471. Their structures were elucidated by. using 1D and 2D NMR analyses in combination with HRESIMS data. The absolute configurations of 1-9 were determined by chemical conversion and comparison of circular dichroism spectra and confirmed for 1 by single-crystal X-ray crystallography. Compounds 6 and 7 have a unique gamma-pyrone-like ring on one side chain. Compounds 2 and 6 inhibited human T cell proliferation with IC50 values of 14.3 and 12.5 mu M, respectively, without obvious cytotoxicity for naive human T cells. Compounds 3 and 6 could weakly enhance insulin-stimulated glucose uptake.
DOI	10.1021/acs.jnatprod.9b00903
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000510076700015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70890
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Kai, Guoyin; Huang, Sheng-Xiong
作者单位	1.Zhejiang Chinese Med Univ, Hangzhou, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Feng-Xian,Huang, Jian-Ping,Liu, Zhixiang,et al. Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(1):111-117.
APA	Yang, Feng-Xian.,Huang, Jian-Ping.,Liu, Zhixiang.,Wang, Zhiyan.,Yang, Jing.,...&Huang, Sheng-Xiong.(2020).Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces.JOURNAL OF NATURAL PRODUCTS,83(1),111-117.
MLA	Yang, Feng-Xian,et al."Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces".JOURNAL OF NATURAL PRODUCTS 83.1(2020):111-117.