Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation
Gao, Junbo1,2; Zhang, Xingjie1; Shang, Kun1; Zhong, Weimao2; Zhang, Ruihan1; Dai, Xiaochang1; Li, Xiaoli1; Wang, Qi1; Zou, Yan1; Xiao, Weilie1
Corresponding AuthorLi, Xiaoli(lixiaoli@ynu.edu.cn) ; Xiao, Weilie(xiaoweilie@ynu.edu.cn)
2020-02-01
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume31Issue:2Pages:427-430
AbstractCallicarpa bodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic. Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids.] and K (1 and 2) and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods. Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
KeywordCallicarpa bodinieri Abietane-type diterpenoids DP4+NMR calculation Anti-inflammation Pyroptosis NLRP3 inflammasome
DOI10.1016/j.cclet.2019.09.020
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000510956700027
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70828
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Xiaoli; Xiao, Weilie
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Gao, Junbo,Zhang, Xingjie,Shang, Kun,et al. Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation[J]. CHINESE CHEMICAL LETTERS,2020,31(2):427-430.
APA Gao, Junbo.,Zhang, Xingjie.,Shang, Kun.,Zhong, Weimao.,Zhang, Ruihan.,...&Xiao, Weilie.(2020).Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation.CHINESE CHEMICAL LETTERS,31(2),427-430.
MLA Gao, Junbo,et al."Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation".CHINESE CHEMICAL LETTERS 31.2(2020):427-430.
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