| Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation | |
| Gao, Junbo1,2; Zhang, Xingjie1; Shang, Kun1; Zhong, Weimao2; Zhang, Ruihan1; Dai, Xiaochang1; Li, Xiaoli1; Wang, Qi1; Zou, Yan1; Xiao, Weilie1 | |
| Corresponding Author | Li, Xiaoli(lixiaoli@ynu.edu.cn) ; Xiao, Weilie(xiaoweilie@ynu.edu.cn) |
| 2020-02-01 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 31Issue:2Pages:427-430 |
| Abstract | Callicarpa bodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic. Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids.] and K (1 and 2) and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods. Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| Keyword | Callicarpa bodinieri Abietane-type diterpenoids DP4+NMR calculation Anti-inflammation Pyroptosis NLRP3 inflammasome |
| DOI | 10.1016/j.cclet.2019.09.020 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000510956700027 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70828 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Li, Xiaoli; Xiao, Weilie |
| Affiliation | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Gao, Junbo,Zhang, Xingjie,Shang, Kun,et al. Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation[J]. CHINESE CHEMICAL LETTERS,2020,31(2):427-430. |
| APA | Gao, Junbo.,Zhang, Xingjie.,Shang, Kun.,Zhong, Weimao.,Zhang, Ruihan.,...&Xiao, Weilie.(2020).Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation.CHINESE CHEMICAL LETTERS,31(2),427-430. |
| MLA | Gao, Junbo,et al."Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation".CHINESE CHEMICAL LETTERS 31.2(2020):427-430. |
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