Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation

doi:10.1016/j.cclet.2019.09.020

	Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation
	Gao, Junbo 1,2; Zhang, Xingjie 1; Shang, Kun 1; Zhong, Weimao 2; Zhang, Ruihan 1; Dai, Xiaochang 1; Li, Xiaoli 1; Wang, Qi 1; Zou, Yan 1; Xiao, Weilie 1
通讯作者	Li, Xiaoli(lixiaoli@ynu.edu.cn) ; Xiao, Weilie(xiaoweilie@ynu.edu.cn)
	2020-02-01
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	31 期号:2 页码:427-430
摘要	Callicarpa bodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic. Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids.] and K (1 and 2) and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods. Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
关键词	Callicarpa bodinieri Abietane-type diterpenoids DP4+NMR calculation Anti-inflammation Pyroptosis NLRP3 inflammasome
DOI	10.1016/j.cclet.2019.09.020
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000510956700027
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70828
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Xiaoli; Xiao, Weilie
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Gao, Junbo,Zhang, Xingjie,Shang, Kun,et al. Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation[J]. CHINESE CHEMICAL LETTERS,2020,31(2):427-430.
APA	Gao, Junbo.,Zhang, Xingjie.,Shang, Kun.,Zhong, Weimao.,Zhang, Ruihan.,...&Xiao, Weilie.(2020).Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation.CHINESE CHEMICAL LETTERS,31(2),427-430.
MLA	Gao, Junbo,et al."Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation".CHINESE CHEMICAL LETTERS 31.2(2020):427-430.