| Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis | |
Ling Yi1,2; Teng Lin-Lin1,2,3; Hua Juan1,2; Li De-Sen1,2,3; Luo Shi-Hong1,2 ; Liu Yan-Chun1,2; Liu Yan1,2; Li Sheng-Hong1,2
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| Corresponding Author | Liu Yan(liuyan@mail.kib.ac.cn) ; Li Sheng-Hong(shli@mail.kib.ac.cn) |
| 2019-12-01 | |
| Source Publication | CHINESE JOURNAL OF NATURAL MEDICINES
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| ISSN | 2095-6975 |
| Volume | 17Issue:12Pages:892-899 |
| Abstract | Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans. Furthermore, leucosceptroid B was found to reduce fat storage, and downregulate the expression of two stearoyl-CoA desaturase (SCD) genes fat-6 and fat-7, and a fatty acid elongase gene elo-2 in wild-type C. elegans. In addition, leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6; fat-7 double mutant. These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6, fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid. These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents. |
| Keyword | Sesterterpenoid Leucosceptroid B Leucosceptrum canum Caenorhabditis elegans Fat accumulation Fatty acid biosynthesis Antilipemic agent |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS Research Area | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| WOS Subject | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| WOS ID | WOS:000504330400004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70667 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Liu Yan; Li Sheng-Hong |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Ling Yi,Teng Lin-Lin,Hua Juan,et al. Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):892-899. |
| APA | Ling Yi.,Teng Lin-Lin.,Hua Juan.,Li De-Sen.,Luo Shi-Hong.,...&Li Sheng-Hong.(2019).Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),892-899. |
| MLA | Ling Yi,et al."Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):892-899. |
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| Ling-2019-Leucoscept（1517KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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