Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels
Xin, Ying1,2; Xu, Min1; Wang, Ya-Feng3; Zheng, Xiao-Hong1; Zhu, Hong-Tao1,4; Wang, Dong1,4; Yang, Chong-Ren1; Zhang, Ying-Jun1,4
Corresponding AuthorZhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
2020-01-24
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Pages8
AbstractA novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester O-glycosyl found mostly in the titled plant growing in Thailand, compound 1 possessed a rare N-beta-glucosamine-2-N-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in 1 was (Z)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or p-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene 5 displayed stronger anti hepatitis B virus (HBV) activity with IC50 values of 1.69 +/- 0.22 and 2.79 +/- 0.69 mu M towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.
KeywordPhyllanthus acidus phyllanthacidoid U norbisabolane sesquiterpenoid amide
DOI10.1080/14786419.2020.1712387
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000509172800001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70650
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhang, Ying-Jun
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Chongqing Three Gorges Med Coll, Chongqing, Peoples R China
3.Zhengzhou Univ, Coll Pharmaceut Sci, Zhengzhou, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Xin, Ying,Xu, Min,Wang, Ya-Feng,et al. Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels[J]. NATURAL PRODUCT RESEARCH,2020:8.
APA Xin, Ying.,Xu, Min.,Wang, Ya-Feng.,Zheng, Xiao-Hong.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2020).Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.NATURAL PRODUCT RESEARCH,8.
MLA Xin, Ying,et al."Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels".NATURAL PRODUCT RESEARCH (2020):8.
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