| Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels | |
Xin, Ying1,2; Xu, Min1; Wang, Ya-Feng3; Zheng, Xiao-Hong1; Zhu, Hong-Tao1,4; Wang, Dong1,4 ; Yang, Chong-Ren1; Zhang, Ying-Jun1,4
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| Corresponding Author | Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn) |
| 2020-01-24 | |
| Source Publication | NATURAL PRODUCT RESEARCH
 |
| ISSN | 1478-6419 |
| Pages | 8 |
| Abstract | A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester O-glycosyl found mostly in the titled plant growing in Thailand, compound 1 possessed a rare N-beta-glucosamine-2-N-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in 1 was (Z)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or p-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene 5 displayed stronger anti hepatitis B virus (HBV) activity with IC50 values of 1.69 +/- 0.22 and 2.79 +/- 0.69 mu M towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively. |
| Keyword | Phyllanthus acidus phyllanthacidoid U norbisabolane sesquiterpenoid amide |
| DOI | 10.1080/14786419.2020.1712387 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000509172800001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70650 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zhang, Ying-Jun |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chongqing Three Gorges Med Coll, Chongqing, Peoples R China 3.Zhengzhou Univ, Coll Pharmaceut Sci, Zhengzhou, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Xin, Ying,Xu, Min,Wang, Ya-Feng,et al. Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels[J]. NATURAL PRODUCT RESEARCH,2020:8. |
| APA | Xin, Ying.,Xu, Min.,Wang, Ya-Feng.,Zheng, Xiao-Hong.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2020).Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.NATURAL PRODUCT RESEARCH,8. |
| MLA | Xin, Ying,et al."Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels".NATURAL PRODUCT RESEARCH (2020):8. |
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