| Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels | |
Xin, Ying1,2; Xu, Min1; Wang, Ya-Feng3; Zheng, Xiao-Hong1; Zhu, Hong-Tao1,4; Wang, Dong1,4 ; Yang, Chong-Ren1; Zhang, Ying-Jun1,4
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| 通讯作者 | Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn) |
| 2020-01-24 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
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| ISSN | 1478-6419 |
| 页码 | 8 |
| 摘要 | A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester O-glycosyl found mostly in the titled plant growing in Thailand, compound 1 possessed a rare N-beta-glucosamine-2-N-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in 1 was (Z)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or p-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene 5 displayed stronger anti hepatitis B virus (HBV) activity with IC50 values of 1.69 +/- 0.22 and 2.79 +/- 0.69 mu M towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively. |
| 关键词 | Phyllanthus acidus phyllanthacidoid U norbisabolane sesquiterpenoid amide |
| DOI | 10.1080/14786419.2020.1712387 |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000509172800001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/70650 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhang, Ying-Jun |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chongqing Three Gorges Med Coll, Chongqing, Peoples R China 3.Zhengzhou Univ, Coll Pharmaceut Sci, Zhengzhou, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xin, Ying,Xu, Min,Wang, Ya-Feng,et al. Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels[J]. NATURAL PRODUCT RESEARCH,2020:8. |
| APA | Xin, Ying.,Xu, Min.,Wang, Ya-Feng.,Zheng, Xiao-Hong.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2020).Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.NATURAL PRODUCT RESEARCH,8. |
| MLA | Xin, Ying,et al."Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels".NATURAL PRODUCT RESEARCH (2020):8. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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