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Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius
Hong, Wei1,2,4; Zhang, Yu3; Yang, Jun1,2,5; Xia, Meng-Yuan1,2,5; Luo, Ji-Feng1,2,5; Li, Xiao-Nian3; Wang, Yue-Hu1,2,5; Wang, Jun-Song4
Corresponding AuthorWang, Yue-Hu(wangyuehu@mail.kib.ac.cn) ; Wang, Jun-Song(wang.junsong@gmail.com)
2019-12-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume82Issue:12Pages:3221-3226
AbstractNine new alkaloids, (+)-1, (-)-1, 2, (+)-3, (-)-3, and 47, along with five known compounds (812), were obtained from the branches and leaves of Elaeocarpus angustifolius. The alkaloids were structurally characterized by NMR and MS data. The absolute configurations of (+)-1, (-)-1, (+)-3, and (-)-3 were determined by comparing their experimental and computed electronic circular dichroism spectra. (+/-)-8,9-Dehydroelaeocarpine (5), (+/-)-9-epielaeocarpine cis-N-oxide trifluoroacetate (6), and (+/-)-elaeocarpine trifluoroacetate (9) exerted weak inhibitory activities against butyrylcholinesterase with IC50 values of 39, 29, and 35 mu M, respectively, while that of tacrine, the positive control, was 0.07 +/- 0.01 mu M. This is the first report of the cholinesterase inhibitory activities of Elaeocarpus alkaloids.
DOI10.1021/acs.jnatprod.8b01027
Indexed BySCI ; SCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000505629000003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70563
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorWang, Yue-Hu; Wang, Jun-Song
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing 210014, Peoples R China
5.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
Recommended Citation
GB/T 7714
Hong, Wei,Zhang, Yu,Yang, Jun,et al. Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(12):3221-3226.
APA Hong, Wei.,Zhang, Yu.,Yang, Jun.,Xia, Meng-Yuan.,Luo, Ji-Feng.,...&Wang, Jun-Song.(2019).Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius.JOURNAL OF NATURAL PRODUCTS,82(12),3221-3226.
MLA Hong, Wei,et al."Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius".JOURNAL OF NATURAL PRODUCTS 82.12(2019):3221-3226.
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