| Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius | |
Hong, Wei1,2,4; Zhang, Yu3 ; Yang, Jun1,2,5; Xia, Meng-Yuan1,2,5; Luo, Ji-Feng1,2,5; Li, Xiao-Nian3; Wang, Yue-Hu1,2,5; Wang, Jun-Song4
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| 通讯作者 | Wang, Yue-Hu(wangyuehu@mail.kib.ac.cn) ; Wang, Jun-Song(wang.junsong@gmail.com) |
| 2019-12-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 82期号:12页码:3221-3226 |
| 摘要 | Nine new alkaloids, (+)-1, (-)-1, 2, (+)-3, (-)-3, and 47, along with five known compounds (812), were obtained from the branches and leaves of Elaeocarpus angustifolius. The alkaloids were structurally characterized by NMR and MS data. The absolute configurations of (+)-1, (-)-1, (+)-3, and (-)-3 were determined by comparing their experimental and computed electronic circular dichroism spectra. (+/-)-8,9-Dehydroelaeocarpine (5), (+/-)-9-epielaeocarpine cis-N-oxide trifluoroacetate (6), and (+/-)-elaeocarpine trifluoroacetate (9) exerted weak inhibitory activities against butyrylcholinesterase with IC50 values of 39, 29, and 35 mu M, respectively, while that of tacrine, the positive control, was 0.07 +/- 0.01 mu M. This is the first report of the cholinesterase inhibitory activities of Elaeocarpus alkaloids. |
| DOI | 10.1021/acs.jnatprod.8b01027 |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000505629000003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/70563 |
| 专题 | 资源植物与生物技术所级重点实验室 |
| 通讯作者 | Wang, Yue-Hu; Wang, Jun-Song |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing 210014, Peoples R China 5.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar |
| 推荐引用方式 GB/T 7714 | Hong, Wei,Zhang, Yu,Yang, Jun,et al. Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(12):3221-3226. |
| APA | Hong, Wei.,Zhang, Yu.,Yang, Jun.,Xia, Meng-Yuan.,Luo, Ji-Feng.,...&Wang, Jun-Song.(2019).Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius.JOURNAL OF NATURAL PRODUCTS,82(12),3221-3226. |
| MLA | Hong, Wei,et al."Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius".JOURNAL OF NATURAL PRODUCTS 82.12(2019):3221-3226. |
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