Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius

doi:10.1021/acs.jnatprod.8b01027

	Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius
	Hong, Wei 1,2,4; Zhang, Yu3 ; Yang, Jun 1,2,5; Xia, Meng-Yuan 1,2,5; Luo, Ji-Feng 1,2,5; Li, Xiao-Nian 3; Wang, Yue-Hu1,2,5 ; Wang, Jun-Song 4
通讯作者	Wang, Yue-Hu(wangyuehu@mail.kib.ac.cn) ; Wang, Jun-Song(wang.junsong@gmail.com)
	2019-12-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	82 期号:12 页码:3221-3226
摘要	Nine new alkaloids, (+)-1, (-)-1, 2, (+)-3, (-)-3, and 47, along with five known compounds (812), were obtained from the branches and leaves of Elaeocarpus angustifolius. The alkaloids were structurally characterized by NMR and MS data. The absolute configurations of (+)-1, (-)-1, (+)-3, and (-)-3 were determined by comparing their experimental and computed electronic circular dichroism spectra. (+/-)-8,9-Dehydroelaeocarpine (5), (+/-)-9-epielaeocarpine cis-N-oxide trifluoroacetate (6), and (+/-)-elaeocarpine trifluoroacetate (9) exerted weak inhibitory activities against butyrylcholinesterase with IC50 values of 39, 29, and 35 mu M, respectively, while that of tacrine, the positive control, was 0.07 +/- 0.01 mu M. This is the first report of the cholinesterase inhibitory activities of Elaeocarpus alkaloids.
DOI	10.1021/acs.jnatprod.8b01027
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000505629000003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70563
专题	资源植物与生物技术所级重点实验室
通讯作者	Wang, Yue-Hu; Wang, Jun-Song
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing 210014, Peoples R China 5.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
推荐引用方式 GB/T 7714	Hong, Wei,Zhang, Yu,Yang, Jun,et al. Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(12):3221-3226.
APA	Hong, Wei.,Zhang, Yu.,Yang, Jun.,Xia, Meng-Yuan.,Luo, Ji-Feng.,...&Wang, Jun-Song.(2019).Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius.JOURNAL OF NATURAL PRODUCTS,82(12),3221-3226.
MLA	Hong, Wei,et al."Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius".JOURNAL OF NATURAL PRODUCTS 82.12(2019):3221-3226.

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