Phlegmadines B and C, two Lycopodium alkaloids with 6/5/5/5/7 pentacyclic skeleton from Phlegmariurus phlegmaria

doi:10.1016/j.tetlet.2019.151381

	Phlegmadines B and C, two Lycopodium alkaloids with 6/5/5/5/7 pentacyclic skeleton from Phlegmariurus phlegmaria
	Zhang, Zhi-Jun; Zhu, Qin-Feng; Wu, Xing-De; Zhao, Qin-Shi
通讯作者	Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn)
	2020-01-09
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	61 期号:2 页码:4
摘要	Two Lycopodium alkaloids named phlegmadines B (1) and C (2), along with biogenetically related known compounds 3-6, were obtained from Phlegmariurus phlegmaria. Their structures were elucidated based on NMR spectroscopic analysis, and the absolute configuration of I was determined by single-crystal X-ray diffraction. Compounds 1 and 2 represent the first pentacyclic (6/5/5/5/7) C16N2 Lycopodium alkaloid skeleton. In addition, a possible biosynthetic pathway for 1 and 2 was proposed. Moreover, compound 1 exhibited moderate neurotrophic effects on PC12 cells. (C) 2019 Elsevier Ltd. All rights reserved.
关键词	Lycopodium alkaloids Phlegmariurus phlegmaria Phlegmadines Neurotrophic effects
DOI	10.1016/j.tetlet.2019.151381
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000509777000005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70537
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhao, Qin-Shi
作者单位	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhi-Jun,Zhu, Qin-Feng,Wu, Xing-De,et al. Phlegmadines B and C, two Lycopodium alkaloids with 6/5/5/5/7 pentacyclic skeleton from Phlegmariurus phlegmaria[J]. TETRAHEDRON LETTERS,2020,61(2):4.
APA	Zhang, Zhi-Jun,Zhu, Qin-Feng,Wu, Xing-De,&Zhao, Qin-Shi.(2020).Phlegmadines B and C, two Lycopodium alkaloids with 6/5/5/5/7 pentacyclic skeleton from Phlegmariurus phlegmaria.TETRAHEDRON LETTERS,61(2),4.
MLA	Zhang, Zhi-Jun,et al."Phlegmadines B and C, two Lycopodium alkaloids with 6/5/5/5/7 pentacyclic skeleton from Phlegmariurus phlegmaria".TETRAHEDRON LETTERS 61.2(2020):4.