| Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens | |
Wang, Bei2,3; Zhao, Yin-Jiao1; Zhao, Yun-Li1,2; Liu, Ya-Ping2; Li, Xiao-Nian2; Zhang, Hongbin1; Luo, Xiao-Dong1,2
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| Corresponding Author | Zhang, Hongbin(zhanghb@ynu.edu.cn) ; Luo, Xiao-Dong(xdluo@mail.kib.ac.cn) |
| 2020-01-03 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 22Issue:1Pages:257-260 |
| Abstract | Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo. |
| DOI | 10.1021/acs.orglett.9b04252 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000506088700053 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70521 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zhang, Hongbin; Luo, Xiao-Dong |
| Affiliation | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Lanzhou Univ Technol, Sch Life Sci & Engn, Key Lab Herbal Tebitan Drug Screening & Deep Proc, Lanzhou 730050, Gansu, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Bei,Zhao, Yin-Jiao,Zhao, Yun-Li,et al. Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens[J]. ORGANIC LETTERS,2020,22(1):257-260. |
| APA | Wang, Bei.,Zhao, Yin-Jiao.,Zhao, Yun-Li.,Liu, Ya-Ping.,Li, Xiao-Nian.,...&Luo, Xiao-Dong.(2020).Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens.ORGANIC LETTERS,22(1),257-260. |
| MLA | Wang, Bei,et al."Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens".ORGANIC LETTERS 22.1(2020):257-260. |
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