Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens

doi:10.1021/acs.orglett.9b04252

	Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens
	Wang, Bei 2,3; Zhao, Yin-Jiao 1; Zhao, Yun-Li 1,2; Liu, Ya-Ping 2; Li, Xiao-Nian 2; Zhang, Hongbin 1; Luo, Xiao-Dong1,2
通讯作者	Zhang, Hongbin(zhanghb@ynu.edu.cn) ; Luo, Xiao-Dong(xdluo@mail.kib.ac.cn)
	2020-01-03
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	22 期号:1 页码:257-260
摘要	Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo.
DOI	10.1021/acs.orglett.9b04252
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000506088700053
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70521
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhang, Hongbin; Luo, Xiao-Dong
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Lanzhou Univ Technol, Sch Life Sci & Engn, Key Lab Herbal Tebitan Drug Screening & Deep Proc, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Wang, Bei,Zhao, Yin-Jiao,Zhao, Yun-Li,et al. Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens[J]. ORGANIC LETTERS,2020,22(1):257-260.
APA	Wang, Bei.,Zhao, Yin-Jiao.,Zhao, Yun-Li.,Liu, Ya-Ping.,Li, Xiao-Nian.,...&Luo, Xiao-Dong.(2020).Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens.ORGANIC LETTERS,22(1),257-260.
MLA	Wang, Bei,et al."Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens".ORGANIC LETTERS 22.1(2020):257-260.