Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis
Li, Wen-Yuan1,2; Liu, Yan1; Lin, Yu-Tian1; Liu, Yan-Chun1; Guo, Kai1; Li, Xiao-Nian1; Luo, Shi-Hong1,3; Li, Sheng-Hong1
Corresponding AuthorLuo, Shi-Hong(luoshihong@syau.edu.cn) ; Li, Sheng-Hong(shli@mail.kib.ac.cn)
2020-02-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume170Pages:7
AbstractFungal endophytes from plants are an important source for discovery of novel bioactive natural products. In this study, five undescribed harziane diterpenoids with a 4/7/5/6 tetracyclic scaffold, harzianols F-J and three known derivatives, were obtained from the liquid fermentation of an endophytic fungus Trichoderma atroviride B7, which was isolated from the healthy flower of a Lamiaceae plant Colquhounia coccinea var. mollis. Their structures were elucidated by comprehensive spectroscopic analyses and X-ray crystallographic diffraction in the case of harzianol F. Harzianol I exhibited significant antibacterial effect against the growth of Staphylococcus aureus (EC50 = 7.7 +/- 0.8 mu g/mL), Bacillus subtilis (EC50 = 7.7 +/- 1.0 mu g/mL), and Micrococcus luteus (EC50 = 9.9 +/- 1.5 mu g/mL). Meanwhile, cytotoxic activity of harzianol I against three cancer cell lines was also observed. A plausible biosynthetic pathway for harziane diterpenoids was proposed.
KeywordTrichoderma atroviride Hypocreaceae Colquhounia coccinea var. mollis Lamiaceae Fungal endophyte Harziane diterpenoids Harzianols F-J Antibacterial activity
DOI10.1016/j.phytochem.2019.112198
Indexed BySCI ; SCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000508761600018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70486
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLuo, Shi-Hong; Li, Sheng-Hong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China
Recommended Citation
GB/T 7714
Li, Wen-Yuan,Liu, Yan,Lin, Yu-Tian,et al. Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis[J]. PHYTOCHEMISTRY,2020,170:7.
APA Li, Wen-Yuan.,Liu, Yan.,Lin, Yu-Tian.,Liu, Yan-Chun.,Guo, Kai.,...&Li, Sheng-Hong.(2020).Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis.PHYTOCHEMISTRY,170,7.
MLA Li, Wen-Yuan,et al."Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis".PHYTOCHEMISTRY 170(2020):7.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Wen-Yuan]'s Articles
[Liu, Yan]'s Articles
[Lin, Yu-Tian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Wen-Yuan]'s Articles
[Liu, Yan]'s Articles
[Lin, Yu-Tian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Wen-Yuan]'s Articles
[Liu, Yan]'s Articles
[Lin, Yu-Tian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.