| Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes | |
| Zhang, Xiaotian1; Yang, Lu2; Wang, Wenjing1; Wu, Zhaodi1; Wang, Jianping1; Sun, Weiguang1; Li, Xiao-Nian3; Chen, Chunmei1; Zhu, Hucheng1; Zhang, Yonghui1 | |
| Corresponding Author | Zhu, Hucheng(zhuhucheng@hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn) |
| 2019-11-01 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| Volume | 82Issue:11Pages:2994-3001 |
| Abstract | Flavipesines A and B (1 and 2) and asperchalasines E-H (3-6), two cytochalasans with an unusual ring system and four merocytochalasans possessing a 5/6/11/5/5/6 ring system, were isolated from Aspergillus flavipes, along with three related compounds (7-9). Their structures, including absolute configurations, were determined on the basis of data from HRESIMS, NMR, ECD, molecular modeling, and single-crystal X-ray diffraction. Flavipesines A and B (1 and 2) represent the first examples of cytochalasans possessing a 5/6/7/6 ring system with a C-18-O-C-21 bridge. Compounds 3, 7, and 9 show moderate inhibitory activities against isocitrate dehydrogenase 1 (IDH1). This is the first report on the IDH1 inhibitory activities of cytochalasans. |
| DOI | 10.1021/acs.jnatprod.9b00512 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000499741400009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70458 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zhu, Hucheng; Zhang, Yonghui |
| Affiliation | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Western Univ, Fac Sci, Dept Chem, 1151 Richmond St, London, ON N6A 3K7, Canada 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Xiaotian,Yang, Lu,Wang, Wenjing,et al. Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(11):2994-3001. |
| APA | Zhang, Xiaotian.,Yang, Lu.,Wang, Wenjing.,Wu, Zhaodi.,Wang, Jianping.,...&Zhang, Yonghui.(2019).Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes.JOURNAL OF NATURAL PRODUCTS,82(11),2994-3001. |
| MLA | Zhang, Xiaotian,et al."Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes".JOURNAL OF NATURAL PRODUCTS 82.11(2019):2994-3001. |
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| Zhang-2019-Flavipesi（1885KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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