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Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome
Li, Ming-Xiang1,2; Bai, Xue3; Ma, Yong-Peng1,2; Zhang, Hong-Xia1,4; Nama, Nuosu5; Pei, Sheng-Ji1,4; Du, Zhi-Zhi1,4
Corresponding AuthorDu, Zhi-Zhi(
AbstractZingiber cassumunar Roxb. is a medically important plant with extensive traditional medicinal functions and bioactivities. It is also used in some skin-care balm by local people. Nevertheless, the research on the active components of the plant related to skin-care is not enough, which mainly involved some antioxidant and anti-inflammatory active compounds. This study investigated the extracts and components from rhizome of Z. cassumunar for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, HDFa collagen secretion promotion, tyrosinase inhibition, and NO generation inhibition activities for the purpose of identifying ingredients with potential anti-aging, skin-whitening, and anti-inflammation for use in cosmetics. Ethyl acetate (EtOAc) extract of the plant showed significant NO generation inhibition, DPPH radical scavenging, tyrosinase inhibitory activities, and weak promoting collagen secretion activity while petroleum ether (PE) extract showed obvious NO generation inhibition activity. Six active compounds, (E)-3-(3,4-dimethoxyphenyl)-2-propenal (1), cis-3-(3,4-dimethoxyphenyl)-4-[(E)-2,4,5-trimehoxystyryl]cyclohex-1-ene (2), 1-feruloyloxy cinnamic acid (3), (1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (4), bisdemethoxycurcumin (5), and curcumin (6), were isolated from PE and EtOAc extracts by bioassay-guided fractionation. 1, 3, 4, 5, and 6 showed significant NO generation inhibition activity with IC50 of 22.67 +/- 2.36, 7.00 +/- 0.22, 15.40 +/- 0.63, 5.47 +/- 0.09, and 7.16 +/- 0.05 mu M, respectively. 3 also showed potent DPPH radical scavenging activity with IC50 of 22.96 +/- 0.87 mu g/mL. 4 was a good tyrosinase inhibitor with the inhibitory rate of 42.56 +/- 1.02% under the concentration of 100 mu g/mL. 2 and 4 showed significant HDFa collagen secretion promoting activity with EC50 of 13.91 +/- 1.56 and 8.50 +/- 1.31 mu g/mL, respectively. This is the first report on components from Z. cassumunar for their HDFa collagen secretion promotion and tyrosinase inhibition activities. These results suggest that medicinal plant Z. cassumunar possesses potential application value in the development of natural cosmeceutical products for anti-aging, skin-whitening, and anti-inflammation activity.
KeywordZingiber cassumunar Roxb. Anti-Inflammatory Antioxidant Tyrosinase inhibitory activity Collagen secretion promoting activity
Indexed BySCI ; SCI
WOS Research AreaAgriculture
WOS SubjectAgricultural Engineering ; Agronomy
WOS IDWOS:000496611800022
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorDu, Zhi-Zhi
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Dr Plant Skin Care Prod Codev Ctr, Kunming 650201, Yunnan, Peoples R China
5.Penn State Univ, Eberly Coll Sci, State Coll, PA 16803 USA
Recommended Citation
GB/T 7714
Li, Ming-Xiang,Bai, Xue,Ma, Yong-Peng,et al. Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome[J]. INDUSTRIAL CROPS AND PRODUCTS,2019,141:7.
APA Li, Ming-Xiang.,Bai, Xue.,Ma, Yong-Peng.,Zhang, Hong-Xia.,Nama, Nuosu.,...&Du, Zhi-Zhi.(2019).Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome.INDUSTRIAL CROPS AND PRODUCTS,141,7.
MLA Li, Ming-Xiang,et al."Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome".INDUSTRIAL CROPS AND PRODUCTS 141(2019):7.
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