Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome

doi:10.1016/j.indcrop.2019.111764

	Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome
	Li, Ming-Xiang 1,2; Bai, Xue 3; Ma, Yong-Peng 1,2; Zhang, Hong-Xia1,4 ; Nama, Nuosu 5; Pei, Sheng-Ji 1,4; Du, Zhi-Zhi1,4
通讯作者	Du, Zhi-Zhi(duzhizhi@mail.kib.ac.cn)
	2019-12-01
发表期刊	INDUSTRIAL CROPS AND PRODUCTS
ISSN	0926-6690
卷号	141 页码:7
摘要	Zingiber cassumunar Roxb. is a medically important plant with extensive traditional medicinal functions and bioactivities. It is also used in some skin-care balm by local people. Nevertheless, the research on the active components of the plant related to skin-care is not enough, which mainly involved some antioxidant and anti-inflammatory active compounds. This study investigated the extracts and components from rhizome of Z. cassumunar for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, HDFa collagen secretion promotion, tyrosinase inhibition, and NO generation inhibition activities for the purpose of identifying ingredients with potential anti-aging, skin-whitening, and anti-inflammation for use in cosmetics. Ethyl acetate (EtOAc) extract of the plant showed significant NO generation inhibition, DPPH radical scavenging, tyrosinase inhibitory activities, and weak promoting collagen secretion activity while petroleum ether (PE) extract showed obvious NO generation inhibition activity. Six active compounds, (E)-3-(3,4-dimethoxyphenyl)-2-propenal (1), cis-3-(3,4-dimethoxyphenyl)-4-[(E)-2,4,5-trimehoxystyryl]cyclohex-1-ene (2), 1-feruloyloxy cinnamic acid (3), (1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (4), bisdemethoxycurcumin (5), and curcumin (6), were isolated from PE and EtOAc extracts by bioassay-guided fractionation. 1, 3, 4, 5, and 6 showed significant NO generation inhibition activity with IC50 of 22.67 +/- 2.36, 7.00 +/- 0.22, 15.40 +/- 0.63, 5.47 +/- 0.09, and 7.16 +/- 0.05 mu M, respectively. 3 also showed potent DPPH radical scavenging activity with IC50 of 22.96 +/- 0.87 mu g/mL. 4 was a good tyrosinase inhibitor with the inhibitory rate of 42.56 +/- 1.02% under the concentration of 100 mu g/mL. 2 and 4 showed significant HDFa collagen secretion promoting activity with EC50 of 13.91 +/- 1.56 and 8.50 +/- 1.31 mu g/mL, respectively. This is the first report on components from Z. cassumunar for their HDFa collagen secretion promotion and tyrosinase inhibition activities. These results suggest that medicinal plant Z. cassumunar possesses potential application value in the development of natural cosmeceutical products for anti-aging, skin-whitening, and anti-inflammation activity.
关键词	Zingiber cassumunar Roxb. Anti-Inflammatory Antioxidant Tyrosinase inhibitory activity Collagen secretion promoting activity
DOI	10.1016/j.indcrop.2019.111764
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000496611800022
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70182
专题	资源植物与生物技术所级重点实验室
通讯作者	Du, Zhi-Zhi
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Dr Plant Skin Care Prod Codev Ctr, Kunming 650201, Yunnan, Peoples R China 5.Penn State Univ, Eberly Coll Sci, State Coll, PA 16803 USA
推荐引用方式 GB/T 7714	Li, Ming-Xiang,Bai, Xue,Ma, Yong-Peng,et al. Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome[J]. INDUSTRIAL CROPS AND PRODUCTS,2019,141:7.
APA	Li, Ming-Xiang.,Bai, Xue.,Ma, Yong-Peng.,Zhang, Hong-Xia.,Nama, Nuosu.,...&Du, Zhi-Zhi.(2019).Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome.INDUSTRIAL CROPS AND PRODUCTS,141,7.
MLA	Li, Ming-Xiang,et al."Cosmetic potentials of extracts and compounds from Zingiber cassumunar Roxb. rhizome".INDUSTRIAL CROPS AND PRODUCTS 141(2019):7.

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