Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata

doi:10.1021/acs.jnatprod.8b00954

	Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata
	Zhu, Guo-Lei 1,2; Wan, Luo-Sheng 1; Peng, Xing-Rong 1; Shi, Qiang-Qiang 1; Li, Xiao-Nian 1; Chen, Jian-Chao 1; Zhou, Lin 1; Qiu, Ming-Hua1
通讯作者	Qiu, Ming-Hua(mhchiu@mail.kib.ac.cn)
	2019-09-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	82 期号:9 页码:2419-2429
摘要	Eight new limonoids, toononoids A-H (1-8), eight new B-seco-29-norlimonoids, toonanoronoids A-H (9-16), and seven known analogues were obtained from the EtOAc extract of the twigs and leaves of Toona ciliata. Compounds 2, 4, 8, and 16 are rare lactam-bearing limonoids. Compounds 1, 14, and 15 possess an unusual gamma-methoxybutenolide moiety at C-17, while compounds 9, 10, and 15 have a rare 3 beta-hydroxy group. Their 2D structure and relative configurations were identified using spectroscopic data. The absolute configurations of 1, 9, 14, and 15 were established via X-ray diffraction crystallography or comparison of experimental and calculated ECD data. The cytotoxicity of the compounds was assessed toward five human tumor cell lines, and their anti-inflammatory activity was assessed based on NO production using LPS-stimulated RAW264.7 macrophages. Compounds 11 and 12 exerted inhibition toward two tumor cell lines (MCF-7, SW-480) with IC50 values between 2.1 and 3.7 mu M, while 18-22 inhibited the proliferation of HL-60, MCF-7, and SW-480 cells (IC50 0.6-4.0 mu M). Only compound 4 exhibited weak anti-inflammatory activity with an IC50 value of 28.3 mu M.
DOI	10.1021/acs.jnatprod.8b00954
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000488424000007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/69988
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Qiu, Ming-Hua
作者单位	1.Chinese Acad Sci, KIB, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Southwest Forestry Univ, Fac Chem Engn, Kunming 650224, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Guo-Lei,Wan, Luo-Sheng,Peng, Xing-Rong,et al. Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(9):2419-2429.
APA	Zhu, Guo-Lei.,Wan, Luo-Sheng.,Peng, Xing-Rong.,Shi, Qiang-Qiang.,Li, Xiao-Nian.,...&Qiu, Ming-Hua.(2019).Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata.JOURNAL OF NATURAL PRODUCTS,82(9),2419-2429.
MLA	Zhu, Guo-Lei,et al."Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata".JOURNAL OF NATURAL PRODUCTS 82.9(2019):2419-2429.