| Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria | |
Zhang, Zhi-Jun1; Wang, Chen2 ; Wu, Xing-De1; Huang, Yan2; Zhou, Wen-Xia2; Zhao, Qin-Shi1
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| Corresponding Author | Zhou, Wen-Xia(zhouwx@bmi.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn) |
| 2019-09-06 | |
| Source Publication | JOURNAL OF ORGANIC CHEMISTRY
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| ISSN | 0022-3263 |
| Volume | 84Issue:17Pages:11301-11305 |
| Abstract | Phlegmadine A (1), a Lycopodium alkaloid with a unique cyclobutane ring and featuring a complex tetracyclo-[4.2.2.0(3,8).0(3,10)]decane-bridged system, together with three biogenetically related known compounds, was isolated from the Phlegmariurus phlegmaria. The structures and absolute configurations of 1 and 2 were determined by NMR and single-crystal X-ray analysis. Among them, compound 2 exhibited noticeable protective effects for long-term potentiation impairment by corticosterone induced in mice. Moreover, we succeeded in the efficient synthesis of 1 from 3 by a biomimetic synthesis method. |
| DOI | 10.1021/acs.joc.9b01723 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000485089200077 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/69461 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zhou, Wen-Xia; Zhao, Qin-Shi |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Zhi-Jun,Wang, Chen,Wu, Xing-De,et al. Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(17):11301-11305. |
| APA | Zhang, Zhi-Jun,Wang, Chen,Wu, Xing-De,Huang, Yan,Zhou, Wen-Xia,&Zhao, Qin-Shi.(2019).Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria.JOURNAL OF ORGANIC CHEMISTRY,84(17),11301-11305. |
| MLA | Zhang, Zhi-Jun,et al."Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria".JOURNAL OF ORGANIC CHEMISTRY 84.17(2019):11301-11305. |
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| Zhang-2019-Phlegmadi（1540KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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