Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria
Zhang, Zhi-Jun1; Wang, Chen2; Wu, Xing-De1; Huang, Yan2; Zhou, Wen-Xia2; Zhao, Qin-Shi1
Corresponding AuthorZhou, Wen-Xia(zhouwx@bmi.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn)
2019-09-06
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume84Issue:17Pages:11301-11305
AbstractPhlegmadine A (1), a Lycopodium alkaloid with a unique cyclobutane ring and featuring a complex tetracyclo-[4.2.2.0(3,8).0(3,10)]decane-bridged system, together with three biogenetically related known compounds, was isolated from the Phlegmariurus phlegmaria. The structures and absolute configurations of 1 and 2 were determined by NMR and single-crystal X-ray analysis. Among them, compound 2 exhibited noticeable protective effects for long-term potentiation impairment by corticosterone induced in mice. Moreover, we succeeded in the efficient synthesis of 1 from 3 by a biomimetic synthesis method.
DOI10.1021/acs.joc.9b01723
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000485089200077
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/69461
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhou, Wen-Xia; Zhao, Qin-Shi
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhi-Jun,Wang, Chen,Wu, Xing-De,et al. Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(17):11301-11305.
APA Zhang, Zhi-Jun,Wang, Chen,Wu, Xing-De,Huang, Yan,Zhou, Wen-Xia,&Zhao, Qin-Shi.(2019).Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria.JOURNAL OF ORGANIC CHEMISTRY,84(17),11301-11305.
MLA Zhang, Zhi-Jun,et al."Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria".JOURNAL OF ORGANIC CHEMISTRY 84.17(2019):11301-11305.
Files in This Item: Download All
File Name/Size DocType Version Access License
Zhang-2019-Phlegmadi(1540KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Zhi-Jun]'s Articles
[Wang, Chen]'s Articles
[Wu, Xing-De]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Zhi-Jun]'s Articles
[Wang, Chen]'s Articles
[Wu, Xing-De]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Zhi-Jun]'s Articles
[Wang, Chen]'s Articles
[Wu, Xing-De]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Zhang-2019-Phlegmadine A_ A Lycopodium Alkaloi.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.