| Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli | |
Chen, Yong-Hong1,2; He, Jiang-Bo1,2,4; Bai, Xue3; Li, Xiao-Nian3; Lu, Lan-Feng1,2; Liu, Yan-Chun3 ; Zhang, Ke-Qin1,2; Li, Sheng-Hong3; Niu, Xue-Mei1,2
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| Corresponding Author | Zhang, Ke-Qin(kqzhang@ynu.edu.cn) ; Li, Sheng-Hong(shli@mail.kib.ac.cn) ; Niu, Xue-Mei(xmniu@ynu.edu.cn) |
| 2019-08-16 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 21Issue:16Pages:6499-6503 |
| Abstract | Here we provide an unprecedented biofactory where fluorescent dye-like complex xanthenes could be produced in an engineered Escherichia coli. Feeding the strain with toluquinol or hydroquinones resulted in production of novel "unnatural" natural products including four arthrocolins embedded with indolyltriphenyl quaternary carbons. Arthrocolins A-C potently inhibited various human cancer cell lines including paclitaxel-resistant cell line A549/Taxol and methicillin-resistant Staphylococcus aureus and immensely restored the sensitivity of intractable fluconazole-resistant human pathogen Candida albicans to fluconazole. |
| DOI | 10.1021/acs.orglett.9b02371 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Organic |
| WOS ID | WOS:000481979100068 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/69457 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zhang, Ke-Qin; Li, Sheng-Hong; Niu, Xue-Mei |
| Affiliation | 1.Yunnan Univ, Sch Life Sci, Minist Educ, State Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Yunnan, Peoples R China 2.Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Sch Life Sci, Kunming 650091, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Kunming Univ, Kunming Key Lab Resp Dis, Kunming 650214, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Yong-Hong,He, Jiang-Bo,Bai, Xue,et al. Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli[J]. ORGANIC LETTERS,2019,21(16):6499-6503. |
| APA | Chen, Yong-Hong.,He, Jiang-Bo.,Bai, Xue.,Li, Xiao-Nian.,Lu, Lan-Feng.,...&Niu, Xue-Mei.(2019).Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli.ORGANIC LETTERS,21(16),6499-6503. |
| MLA | Chen, Yong-Hong,et al."Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli".ORGANIC LETTERS 21.16(2019):6499-6503. |
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