Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli
Chen, Yong-Hong1,2; He, Jiang-Bo1,2,4; Bai, Xue3; Li, Xiao-Nian3; Lu, Lan-Feng1,2; Liu, Yan-Chun3; Zhang, Ke-Qin1,2; Li, Sheng-Hong3; Niu, Xue-Mei1,2
Corresponding AuthorZhang, Ke-Qin(kqzhang@ynu.edu.cn) ; Li, Sheng-Hong(shli@mail.kib.ac.cn) ; Niu, Xue-Mei(xmniu@ynu.edu.cn)
2019-08-16
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:16Pages:6499-6503
AbstractHere we provide an unprecedented biofactory where fluorescent dye-like complex xanthenes could be produced in an engineered Escherichia coli. Feeding the strain with toluquinol or hydroquinones resulted in production of novel "unnatural" natural products including four arthrocolins embedded with indolyltriphenyl quaternary carbons. Arthrocolins A-C potently inhibited various human cancer cell lines including paclitaxel-resistant cell line A549/Taxol and methicillin-resistant Staphylococcus aureus and immensely restored the sensitivity of intractable fluconazole-resistant human pathogen Candida albicans to fluconazole.
DOI10.1021/acs.orglett.9b02371
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000481979100068
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/69457
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhang, Ke-Qin; Li, Sheng-Hong; Niu, Xue-Mei
Affiliation1.Yunnan Univ, Sch Life Sci, Minist Educ, State Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Sch Life Sci, Kunming 650091, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Kunming Univ, Kunming Key Lab Resp Dis, Kunming 650214, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Chen, Yong-Hong,He, Jiang-Bo,Bai, Xue,et al. Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli[J]. ORGANIC LETTERS,2019,21(16):6499-6503.
APA Chen, Yong-Hong.,He, Jiang-Bo.,Bai, Xue.,Li, Xiao-Nian.,Lu, Lan-Feng.,...&Niu, Xue-Mei.(2019).Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli.ORGANIC LETTERS,21(16),6499-6503.
MLA Chen, Yong-Hong,et al."Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli".ORGANIC LETTERS 21.16(2019):6499-6503.
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