Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense
Li, Qiong2; Zhao, Yun-Li1,2; Long, Cheng-Bo3; Zhu, Pei-Feng2; Liu, Ya-Ping2; Luo, Xiao-Dong1,2
Corresponding AuthorLuo, Xiao-Dong(xdluo@mail.kib.ac.cn)
2019-11-15
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
Volume244Pages:7
AbstractEthnopharmacological relevance: Veratrum taliense is traditionally used TCMs in Yunnan province of China for pain and inflammation. Previous research and clinical applications have shown that V. taliense had significant analgesic activity. Jevine-type alkaloids were shown to be one of the anti-inflammatory and analgesic agents from V. taliense. However, other types of compounds from V. taliense related to its traditional use remains unknown. Aim of the study: To identify veratramine-type steroidal alkaloids with analgesic effects from the roots and rhizomes of V. taliense. Materials and methods: Compounds were isolated from the roots and rhizomes of V. taliense by chromatographic separation. Their structures were elucidated based on UV, IR, NMR and MS spectra data. Analgesic activity was assessed with acetic acid-induced writhing in mice model. Results: Seven new veratramine-type alkaloids were isolated from the roots and rhizomes of V. taliense. They all exhibited significant analgesic activity, of which alkaloids 1 and 4 were more potent antalgic than the well-known analgesic drug, pethidine. Conclusions: The veratramine-type alkaloids from V. taliense may serve as new leads for the discovery of analgesic drugs.
KeywordV. taliense Veratrum Liliaceae Veratramine-type alkaloids Analgesic activity
DOI10.1016/j.jep.2019.112137
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000486357500019
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/69441
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLuo, Xiao-Dong
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Qiong,Zhao, Yun-Li,Long, Cheng-Bo,et al. Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,244:7.
APA Li, Qiong,Zhao, Yun-Li,Long, Cheng-Bo,Zhu, Pei-Feng,Liu, Ya-Ping,&Luo, Xiao-Dong.(2019).Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense.JOURNAL OF ETHNOPHARMACOLOGY,244,7.
MLA Li, Qiong,et al."Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense".JOURNAL OF ETHNOPHARMACOLOGY 244(2019):7.
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