| Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense | |
Li, Qiong2; Zhao, Yun-Li1,2; Long, Cheng-Bo3; Zhu, Pei-Feng2; Liu, Ya-Ping2; Luo, Xiao-Dong1,2
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| 通讯作者 | Luo, Xiao-Dong(xdluo@mail.kib.ac.cn) |
| 2019-11-15 | |
| 发表期刊 | JOURNAL OF ETHNOPHARMACOLOGY
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| ISSN | 0378-8741 |
| 卷号 | 244页码:7 |
| 摘要 | Ethnopharmacological relevance: Veratrum taliense is traditionally used TCMs in Yunnan province of China for pain and inflammation. Previous research and clinical applications have shown that V. taliense had significant analgesic activity. Jevine-type alkaloids were shown to be one of the anti-inflammatory and analgesic agents from V. taliense. However, other types of compounds from V. taliense related to its traditional use remains unknown. Aim of the study: To identify veratramine-type steroidal alkaloids with analgesic effects from the roots and rhizomes of V. taliense. Materials and methods: Compounds were isolated from the roots and rhizomes of V. taliense by chromatographic separation. Their structures were elucidated based on UV, IR, NMR and MS spectra data. Analgesic activity was assessed with acetic acid-induced writhing in mice model. Results: Seven new veratramine-type alkaloids were isolated from the roots and rhizomes of V. taliense. They all exhibited significant analgesic activity, of which alkaloids 1 and 4 were more potent antalgic than the well-known analgesic drug, pethidine. Conclusions: The veratramine-type alkaloids from V. taliense may serve as new leads for the discovery of analgesic drugs. |
| 关键词 | V. taliense Veratrum Liliaceae Veratramine-type alkaloids Analgesic activity |
| DOI | 10.1016/j.jep.2019.112137 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000486357500019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/69441 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Luo, Xiao-Dong |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiong,Zhao, Yun-Li,Long, Cheng-Bo,et al. Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,244:7. |
| APA | Li, Qiong,Zhao, Yun-Li,Long, Cheng-Bo,Zhu, Pei-Feng,Liu, Ya-Ping,&Luo, Xiao-Dong.(2019).Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense.JOURNAL OF ETHNOPHARMACOLOGY,244,7. |
| MLA | Li, Qiong,et al."Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense".JOURNAL OF ETHNOPHARMACOLOGY 244(2019):7. |
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