| A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis | |
Guo, Xiaowei1,2,3; Wang, Jidong4; Su, Can2,3; Liu, Chongxi1,2,3; Ma, Xiao-Yan2,3; Yu, Zhiyin1,2,3; Li, Jiansong4; Wang, Xiangjing1; Xiang, Wensheng1; Huang, Sheng-Xiong2,3
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| 通讯作者 | Xiang, Wensheng(xiangwensheng@neau.edu.cn) ; Huang, Sheng-Xiong(sxhuang@mail.kib.ac.cn) |
| 2019-09-21 | |
| 发表期刊 | ORGANIC CHEMISTRY FRONTIERS
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| ISSN | 2052-4129 |
| 卷号 | 6期号:18页码:3215-3219 |
| 摘要 | Chemical investigation of a soil actinomycete strain Streptomyces gamaensis NEAU-Gz11 led to the isolation of three alkaloids 1-3 with antiviral activity. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compound 1 possesses a new and unique spiro-beta-triazinedione-gamma-hydantoin skeleton. The racemic feature and the chemical conversion experiments led us to propose a biosynthetic pathway for 1. Compound 1 (100 mg L-1) showed a strong anti-TMV (tobacco mosaic virus, TMV) activity on the host plants of tomatoes and peppers with inhibition rates of 72.34% and 62.09%, respectively. |
| DOI | 10.1039/c9qo00742c |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000484960000003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/68775 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Xiang, Wensheng; Huang, Sheng-Xiong |
| 作者单位 | 1.Northeast Agr Univ, Heilongjiang Prov Key Lab Agr Microbiol, 59 Mucai St, Harbin 150030, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China 4.Zhejiang Hisun Pharmaceut Co Ltd, Zhejiang Key Lab Antifungal Drugs, Taizhou 318000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Xiaowei,Wang, Jidong,Su, Can,et al. A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(18):3215-3219. |
| APA | Guo, Xiaowei.,Wang, Jidong.,Su, Can.,Liu, Chongxi.,Ma, Xiao-Yan.,...&Huang, Sheng-Xiong.(2019).A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis.ORGANIC CHEMISTRY FRONTIERS,6(18),3215-3219. |
| MLA | Guo, Xiaowei,et al."A unique spiro-beta-triazinedione-gamma-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis".ORGANIC CHEMISTRY FRONTIERS 6.18(2019):3215-3219. |
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| guo2019.pdf（1243KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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