| Whole-brain mapping of projection from mouse lateral septal nucleus | |
Deng, Ke1,2; Yang, Lu3; Xie, Jing1,2; Tang, He1; Wu, Gui-Sheng3 ; Luo, Huai-Rong1,3
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| 通讯作者 | Luo, Huai-Rong(luohuairong@mail.kib.ac.cn) |
| 2019-07-01 | |
| 发表期刊 | BIOLOGY OPEN
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| ISSN | 2046-6390 |
| 卷号 | 8期号:7页码:9 |
| 摘要 | The lateral septal nucleus (LS) plays a critical role in emotionality, social behavior and feeding processes, through neural connections with the hippocampus and hypothalamus. We investigated the neural circuits of LS by using herpes simplex virus 1 strain H129 (H129) and pseudorabies virus stain Bartha (PRV). Virus H129 indicates that LS directly projects to some cerebral nuclei (nucleus accumbens, bed nuclei of the stria terminalis and amygdala), part of the hypothalamus (median preoptic, paraventricular, dorsomedial nucleus and lateral area), thalamus (medial habenula, the paraventricular, parataenial and reuniens nuclei, and the medial line nuclei) and the pontine central gray. Then the LS has secondary projections to the CA3 and CA1 field of the hippocampal formation, lateral and medial preoptic area, and the mammillary body. PRV tracing shows that LS are mainly receiving primary inputs from the amygdala, hippocampus, hypothalamic, thalamus, midbrain and hindbrain, and secondary inputs from dorsal and central linear nucleus raphe, the lateral part of the superior central nucleus raphe, the ventral anterior-lateral complex, the intermediodorsal nucleus, the central medial nucleus, the rhomboid nucleus, and the submedial nucleus of the thalamus. The neural circuit data revealed here could help to understand and further research on the function of LS. |
| 关键词 | Lateral septal nucleus H129 PRV Neural circuits Neural projection |
| DOI | 10.1242/bio.043554 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000478023300015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/68230 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Luo, Huai-Rong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Southwest Med Univ, Sch Pharm, Dept Pharmacol, Key Lab Aging & Regenerat Med, Luzhou 646000, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Ke,Yang, Lu,Xie, Jing,et al. Whole-brain mapping of projection from mouse lateral septal nucleus[J]. BIOLOGY OPEN,2019,8(7):9. |
| APA | Deng, Ke,Yang, Lu,Xie, Jing,Tang, He,Wu, Gui-Sheng,&Luo, Huai-Rong.(2019).Whole-brain mapping of projection from mouse lateral septal nucleus.BIOLOGY OPEN,8(7),9. |
| MLA | Deng, Ke,et al."Whole-brain mapping of projection from mouse lateral septal nucleus".BIOLOGY OPEN 8.7(2019):9. |
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| Deng-2019-Whole-brai（24131KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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