Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans

doi:10.1021/acs.orglett.9b01680

	Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans
	Li, Qin 1; Chen, Chunmei 1; He, Yan 3; Guan, Danyingzi 1; Cheng, Li 1,2; Hao, Xincai 2; Wei, Mengsha 1; Zheng, Yinyu 1; Liu, Chang 1; Li, Xiao-Nian 4; Zhou, Qun 1; Zhu, Hucheng 1; Zhang, Yonghui 1
通讯作者	Zhu, Hucheng(zhuhucheng@hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
	2019-07-05
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	21 期号:13 页码:5091-5095
摘要	Emeriones A-C (1-3), three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities, were isolated from Emericella nidulans. An additional peroxide bridge in compound 3 led to the construction of an unexpected 7,8-dioxatricyclo[4.2.2.0(2,5)] decene scaffold. The structures of 1-3 were elucidated by comprehensive spectroscopic techniques, and their absolute configurations were confirmed by single-crystal X-ray crystallographic analyses and ECD calculations. Compound 1 shows weak inhibitory effects on NO production in LPS-induced RAW264.7 cells.
DOI	10.1021/acs.orglett.9b01680
收录类别	SCI
语种	英语
WOS记录号	WOS:000474795200036
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67961
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhu, Hucheng; Zhang, Yonghui
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Hubei Univ Med, Coll Pharm, Hubei Engn Technol Ctr Comprehens Utilizat Med Pl, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Qin,Chen, Chunmei,He, Yan,et al. Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans[J]. ORGANIC LETTERS,2019,21(13):5091-5095.
APA	Li, Qin.,Chen, Chunmei.,He, Yan.,Guan, Danyingzi.,Cheng, Li.,...&Zhang, Yonghui.(2019).Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans.ORGANIC LETTERS,21(13),5091-5095.
MLA	Li, Qin,et al."Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans".ORGANIC LETTERS 21.13(2019):5091-5095.

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