| SIRT1 inhibitory compounds from the roots of Codonopsis pilosula | |
| Li, Xiao-Zhen1,2; Cheng, Li-Zhi3; Yan, Yong-Ming3; Liu, Bao-Hua3; Cheng, Yong-Xian1,3,4 | |
| 通讯作者 | Cheng, Yong-Xian(yxcheng@mail.kib.ac.cn) |
| 2019-01-02 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| ISSN | 1028-6020 |
| 卷号 | 21期号:1页码:25-32 |
| 摘要 | Three new compounds, pilosulinene A (1), pilosulinols A (2), and B (3), along with seven known compounds, were isolated from the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan Province. The structures of new compounds were established by spectroscopic methods. In particular, the presence of an aromatic ring in the structure of 1 makes it intriguing. The inhibitory activity of compounds against SIRT1 was evaluated. The results showed that 8 could inhibit Sirt1 in a dose-dependent manner. |
| 关键词 | Codonopsis pilosula pilosulinene A pilosulinols A and B triterpenoids Sirt1 |
| DOI | 10.1080/10286020.2017.1422491 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000464571700004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67622 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng, Yong-Xian |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ Tradit Chinese Med, Sch Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Shenzhen 518060, Peoples R China 4.Henan Univ Tradit Med, Sch Pharm, Zhengzhou 450008, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Zhen,Cheng, Li-Zhi,Yan, Yong-Ming,et al. SIRT1 inhibitory compounds from the roots of Codonopsis pilosula[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019,21(1):25-32. |
| APA | Li, Xiao-Zhen,Cheng, Li-Zhi,Yan, Yong-Ming,Liu, Bao-Hua,&Cheng, Yong-Xian.(2019).SIRT1 inhibitory compounds from the roots of Codonopsis pilosula.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,21(1),25-32. |
| MLA | Li, Xiao-Zhen,et al."SIRT1 inhibitory compounds from the roots of Codonopsis pilosula".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 21.1(2019):25-32. |
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| li2018 (2).pdf（1171KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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