SIRT1 inhibitory compounds from the roots of Codonopsis pilosula

doi:10.1080/10286020.2017.1422491

	SIRT1 inhibitory compounds from the roots of Codonopsis pilosula
	Li, Xiao-Zhen 1,2; Cheng, Li-Zhi 3; Yan, Yong-Ming 3; Liu, Bao-Hua 3; Cheng, Yong-Xian 1,3,4
通讯作者	Cheng, Yong-Xian(yxcheng@mail.kib.ac.cn)
	2019-01-02
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN	1028-6020
卷号	21 期号:1 页码:25-32
摘要	Three new compounds, pilosulinene A (1), pilosulinols A (2), and B (3), along with seven known compounds, were isolated from the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan Province. The structures of new compounds were established by spectroscopic methods. In particular, the presence of an aromatic ring in the structure of 1 makes it intriguing. The inhibitory activity of compounds against SIRT1 was evaluated. The results showed that 8 could inhibit Sirt1 in a dose-dependent manner.
关键词	Codonopsis pilosula pilosulinene A pilosulinols A and B triterpenoids Sirt1
DOI	10.1080/10286020.2017.1422491
收录类别	SCI
语种	英语
WOS记录号	WOS:000464571700004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67622
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ Tradit Chinese Med, Sch Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Shenzhen 518060, Peoples R China 4.Henan Univ Tradit Med, Sch Pharm, Zhengzhou 450008, Henan, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-Zhen,Cheng, Li-Zhi,Yan, Yong-Ming,et al. SIRT1 inhibitory compounds from the roots of Codonopsis pilosula[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019,21(1):25-32.
APA	Li, Xiao-Zhen,Cheng, Li-Zhi,Yan, Yong-Ming,Liu, Bao-Hua,&Cheng, Yong-Xian.(2019).SIRT1 inhibitory compounds from the roots of Codonopsis pilosula.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,21(1),25-32.
MLA	Li, Xiao-Zhen,et al."SIRT1 inhibitory compounds from the roots of Codonopsis pilosula".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 21.1(2019):25-32.

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