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Complete loss of RNA editing from the plastid genome and most highly expressed mitochondrial genes of Welwitschia mirabilis
Fan, Weishu1,2,3; Guo, Wenhu2,4; Funk, Lexis2,4; Mower, Jeffrey P.2,3; Zhu, Andan1
Corresponding AuthorMower, Jeffrey P.(jpmower@unl.edu) ; Zhu, Andan(zhuandan@mail.kib.ac.cn)
2019-04-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
Volume62Issue:4Pages:498-506
AbstractComparative genomics among gymnosperms suggested extensive loss of mitochondrial RNA editing sites from Welwitschia mirabilis based on predictive analysis. However, empirical or transcriptome data to confirm this massive loss event are lacking, and the potential mechanisms of RNA site loss are unclear. By comparing genomic sequences with transcriptomic and reverse-transcription PCR sequencing data, we performed a comprehensive analysis of the pattern of RNA editing in the mitochondrial and plastid genomes (mitogenome and plastome, respectively) of W. mirabilis and a second gymnosperm, Ginkgo biloba. For W. mirabilis, we found only 99 editing sites located in 13 protein-coding genes in the mitogenome and a complete loss of RNA editing from the plastome. The few genes having high editing frequency in the Welwitschia mitogenome showed a strong negative correlation with gene expression level. Comparative analyses with G. biloba, containing 1,405 mitochondrial and 345 plastid editing sites, revealed that the editing loss from W. mirabilis is mainly due to the substitution of editable cytidines to thymidines at the genomic level, which could be caused by retroprocessing. Our result is the first study to uncover massive editing loss from both the mitogenome and plastome in a single genus. Furthermore, our results suggest that gene expression level and retroprocessing both contributed to the evolution of RNA editing in plant organellar genomes.
KeywordRNA editing massive loss expression levels organelle genomes Welwitschia
DOI10.1007/s11427-018-9450-1
Indexed BySCI
Language英语
WOS IDWOS:000464901000006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67604
Collection中国西南野生生物种质资源库
Corresponding AuthorMower, Jeffrey P.; Zhu, Andan
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Kunming 650201, Yunnan, Peoples R China
2.Univ Nebraska, Ctr Plant Sci Innovat, Lincoln, NE 68588 USA
3.Univ Nebraska, Dept Agron & Hort, Lincoln, NE 68583 USA
4.Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA
Recommended Citation
GB/T 7714
Fan, Weishu,Guo, Wenhu,Funk, Lexis,et al. Complete loss of RNA editing from the plastid genome and most highly expressed mitochondrial genes of Welwitschia mirabilis[J]. SCIENCE CHINA-LIFE SCIENCES,2019,62(4):498-506.
APA Fan, Weishu,Guo, Wenhu,Funk, Lexis,Mower, Jeffrey P.,&Zhu, Andan.(2019).Complete loss of RNA editing from the plastid genome and most highly expressed mitochondrial genes of Welwitschia mirabilis.SCIENCE CHINA-LIFE SCIENCES,62(4),498-506.
MLA Fan, Weishu,et al."Complete loss of RNA editing from the plastid genome and most highly expressed mitochondrial genes of Welwitschia mirabilis".SCIENCE CHINA-LIFE SCIENCES 62.4(2019):498-506.
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