| Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii | |
Zhan, Rui1; Hu, You-Tian2; Shao, Li-Dong3; Qin, Xu-Jie4 ; Kuang, Fang1; Du, Shou-Zhen1; Wu, Fang2; Chen, Ye-Gao1
| |
| 通讯作者 | Wu, Fang(fang.wu@sjtu.edu.cn) ; Chen, Ye-Gao(ygchen48@126.com) |
| 2019-05-17 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 21期号:10页码:3678-3681 |
| 摘要 | Horisfieldones A (1) and B (2), two dimeric diarylpropanes featuring an unprecedentedly aromatic ring-contracted framework, were isolated from Horsfieldia kingii. Their structures and absolute configurations were determined by the inspection of extensive spectroscopic data and electronic circular dichroism calculations. Molecular modeling analysis, in vitro enzyme-based bioassays, and structure-activity relationship analysis of these isolates revealed that (+)-1 (IC50 = 35.1 +/- 3.9 mu M, SI > 11.4) could present a new class of human DOPA decarboxylase inhibitor. |
| DOI | 10.1021/acs.orglett.9b01125 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000468696100044 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67526 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Wu, Fang; Chen, Ye-Gao |
| 作者单位 | 1.Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China 3.Yunnan Univ Chinese Med, Dept Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhan, Rui,Hu, You-Tian,Shao, Li-Dong,et al. Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii[J]. ORGANIC LETTERS,2019,21(10):3678-3681. |
| APA | Zhan, Rui.,Hu, You-Tian.,Shao, Li-Dong.,Qin, Xu-Jie.,Kuang, Fang.,...&Chen, Ye-Gao.(2019).Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii.ORGANIC LETTERS,21(10),3678-3681. |
| MLA | Zhan, Rui,et al."Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii".ORGANIC LETTERS 21.10(2019):3678-3681. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Zhan-2019-Horisfield（2052KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论