Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii
Zhan, Rui1; Hu, You-Tian2; Shao, Li-Dong3; Qin, Xu-Jie4; Kuang, Fang1; Du, Shou-Zhen1; Wu, Fang2; Chen, Ye-Gao1
Corresponding AuthorWu, Fang(fang.wu@sjtu.edu.cn) ; Chen, Ye-Gao(ygchen48@126.com)
2019-05-17
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:10Pages:3678-3681
AbstractHorisfieldones A (1) and B (2), two dimeric diarylpropanes featuring an unprecedentedly aromatic ring-contracted framework, were isolated from Horsfieldia kingii. Their structures and absolute configurations were determined by the inspection of extensive spectroscopic data and electronic circular dichroism calculations. Molecular modeling analysis, in vitro enzyme-based bioassays, and structure-activity relationship analysis of these isolates revealed that (+)-1 (IC50 = 35.1 +/- 3.9 mu M, SI > 11.4) could present a new class of human DOPA decarboxylase inhibitor.
DOI10.1021/acs.orglett.9b01125
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000468696100044
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67526
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWu, Fang; Chen, Ye-Gao
Affiliation1.Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China
3.Yunnan Univ Chinese Med, Dept Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhan, Rui,Hu, You-Tian,Shao, Li-Dong,et al. Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii[J]. ORGANIC LETTERS,2019,21(10):3678-3681.
APA Zhan, Rui.,Hu, You-Tian.,Shao, Li-Dong.,Qin, Xu-Jie.,Kuang, Fang.,...&Chen, Ye-Gao.(2019).Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii.ORGANIC LETTERS,21(10),3678-3681.
MLA Zhan, Rui,et al."Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii".ORGANIC LETTERS 21.10(2019):3678-3681.
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