Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production
Ding, Lin-Fen1,2,3; Liu, Jiang-Xin1; Xie, Zhang-Qiao1,2,3; Wang, De-Shen1,2,3; Nie, Wei1,2,3; Song, Liu-Dong2,3; Wu, Xing-De1; Zhao, Qin-Shi1
Corresponding AuthorWu, Xing-De(wuxingde@mail.kib.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn)
2019-06-01
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume31Pages:121-124
AbstractFour new elemane sesquiterpenoids, magnograndins J-M (1-4), and one known sesquiterpenoid, 12,13-diacetoxyelema-1,3-dien-6 alpha,11-diol (5), were obtained from 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were determined with extensive spectroscopic (HRMS, IR, 1D and 2D NMR) analyses. Compound 1 represented the first example of elemane sesquiterpenoid with an orthoacetate unit. Compound 4 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 value of 17.83 mu M.
KeywordMagnolia grandiflora Elemane sesquiterpenoid Nitric oxide (NO)
DOI10.1016/j.phytol.2019.03.021
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS IDWOS:000469429200022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67424
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWu, Xing-De; Zhao, Qin-Shi
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Ding, Lin-Fen,Liu, Jiang-Xin,Xie, Zhang-Qiao,et al. Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production[J]. PHYTOCHEMISTRY LETTERS,2019,31:121-124.
APA Ding, Lin-Fen.,Liu, Jiang-Xin.,Xie, Zhang-Qiao.,Wang, De-Shen.,Nie, Wei.,...&Zhao, Qin-Shi.(2019).Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production.PHYTOCHEMISTRY LETTERS,31,121-124.
MLA Ding, Lin-Fen,et al."Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production".PHYTOCHEMISTRY LETTERS 31(2019):121-124.
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